Influence of early-life parental severe life events on the risk of type 1 diabetes in children: the DiPiS study

Acta Diabetologica
Markus LundgrenDiPiS study group

Abstract

Stress and severe life events (SLEs) modify autoimmune disease susceptibility. Here, we aimed to establish if SLEs reported by parents during the first 2 years of life influence the risk of developing type 1 diabetes (T1D) using data from the prospective Diabetes Prediction in Skåne (DiPiS) study. Prospective questionnaire data recorded at 2 months (n = 23,187) and 2 years of age (n = 3784) from the DiPiS cohort of children were included in the analysis. SLEs were analyzed both by groups and as a combined variable. A Cox proportional hazards model was used to calculate hazard ratios (HRs) for T1D diagnosis for the total cohort and for the HLA-DQ2/8 high-risk population. Affected first-degree relatives, HLA-DQ risk group, paternal education level, and parents' country of birth were included as covariates. There was a significantly increased risk of T1D in children with SLEs occurring during the child's first 2 years of life for both the total cohort (HR 1.67; 95% CI 1.1, 2.7; p = 0.03) and the DQ2/8 cohort (HR 2.2; 95% CI 1.1, 4.2; p = 0.018). Subgroup analysis of events related to unemployment, divorce, or family conflict showed a significant hazard for these events occurring both during and after pregnancy in the DQ2/8 cohort ...Continue Reading

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Citations

Feb 16, 2019·Stress and Health : Journal of the International Society for the Investigation of Stress·Roswith RothUNKNOWN TEDDY Study Group
Nov 18, 2019·Endocrine Regulations·Forouzan SadeghimahalliRavieh Golchoobian
Nov 5, 2020·Journal of Neuroendocrinology·William Kenkel

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