PMID: 417765Mar 1, 1978

Influence of EGTA on an exercise-induced elevation in the colonic temperature of the rat

Brain Research Bulletin
N C WilsonM I Phillips


The purpose of this study was to determine if an exercise-induced rise in body temperature could be affected by the chelation of Ca++ in the extracellular fluid surrounding the hypothalamus of the rat. Following the implantation of a guide tube above the hypothalamus, each animal was familiarized with exercising on a motor-driven treadmill. In random order, on separate days, a solution containing 3.6 mM EGTA, 26 mM Ca++ or an artificial cerebrospinal fluid (ACSF) solution was perfused through the guide tube while the animal was running. Colonic (Tc) and tail-skin (Tt) temperatures were monitored continuously. The perfusion of EGTA produced a significant increase in Tc when compared with the perfusion of the ACSF solution. The perfusion of excess Ca++ produced a significant decrease in Tc. These results suggest that Ca++ may play an important role in the mediation of heat dissipation during exercise.


Jan 1, 1974·Pflügers Archiv : European journal of physiology·B Sadowski, E Szczepańska-Sadowska
May 1, 1970·The Journal of Physiology·B Katz, R Miledi

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Heat Loss
Taenia Coli
Egtazic Acid Potassium Salt
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Extracellular Space
Organum Vasculosum Laminae Terminalis
Rats, Laboratory

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