Influence of encapsulation on staphylococcal opsonization and phagocytosis by human polymorphonuclear leukocytes.

Infection and Immunity
P K PetersonP G Quie

Abstract

In previous studies, encapsulated Staphylococcus aureus strains have been shown to resist phagocytosis. In this investigation, the nature of the interference with phagocytosis by human polymorphonuclear leukocytes was examined by studying the opsonization of two pairs of unencapsulated (Smith compact and M variant) and encapsulated (Smith diffuse and M) S. aureus strains. The uptake of [3H]glycine-labeled bacteria by normal leukocytes was quantitatively measured after incubation of bacteria in pooled serum, C2-deficient serum, immunoglobulin-deficient serum, and serum from a rabbit immunized with S. aureus M. The presence of a capsule was found to interfere with opsonization by both the classical and alternative pathways of complement as well as by heat-stable opsonic factors in nonimmune human serum. This interference was significantly greater in the case of the S. aureus M strain than in the case of the Smith diffuse strain. The only effective opsonic source for S. aureus M was immune rabbit serum. It is proposed that encapsulation of S. aureus strains interferes with phagocytosis by preventing effective bacterial opsonization.

References

Oct 1, 1977·The Journal of Infectious Diseases·P K PetersonP G Quie
Mar 1, 1977·Infection and Immunity·P K PetersonP G Quie
Jul 31, 1974·Annals of the New York Academy of Sciences·B B Wiley, N H Maverakis
Aug 1, 1974·Infection and Immunity·M A MellyJ H Hash
Jul 23, 1965·Annals of the New York Academy of Sciences·M G Koenig, M A Melly
Aug 1, 1969·Journal of Medical Microbiology·A C Scott
Mar 1, 1968·Journal of Bacteriology·B B Wiley, N H Maverakis
Nov 1, 1962·The Journal of Experimental Medicine·M G KOENIGD E ROGERS
Nov 1, 1970·Infection and Immunity·K Yoshida, Y Takeuchi

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Citations

Mar 1, 1982·Journal of Periodontal Research·G SundqvistE Johansson
Apr 15, 1981·The Veterinary Quarterly·H A Verbrugh
Sep 10, 2003·Journal of Leukocyte Biology·Jacob D JohnsonJoan M Cook-Mills
Jul 31, 2008·Expert Review of Vaccines·John R Middleton
Dec 1, 1987·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·T MattilaA J Frost
May 24, 1984·The New England Journal of Medicine·J N Sheagren
Sep 1, 1990·Journal of Veterinary Pharmacology and Therapeutics·M SandholmS Pyörälä
Jan 6, 2000·The Journal of Experimental Medicine·C A ThomasJ El Khoury
Sep 19, 2000·The Journal of Veterinary Medical Science·C Y HwangH R Han
Aug 1, 1991·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·W MamoP Jonsson
Oct 1, 1991·Journal of Dairy Science·A J GuidryL M Berning
Oct 1, 1993·Scandinavian Journal of Dental Research·E KerosuoK Lounatmaa
Aug 24, 2001·Journal of Dairy Science·C N O'BrienD C Westhoff
Jan 17, 2004·Clinical Microbiology Reviews·Katherine O'Riordan, Jean C Lee
Oct 17, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dong-Jun JungBok Luel Lee
Jan 1, 1980·Scandinavian Journal of Infectious Diseases. Supplementum
Jan 1, 1995·Eye·M J ElderJ K Dart
Jan 1, 1994·Springer Seminars in Immunopathology·M C Moffitt, M M Frank
Dec 20, 2005·The Journal of Pathology·Hitoshi KomatsuzawaMotoyuki Sugai
Jun 1, 1997·FEMS Microbiology Reviews·T J BeveridgeS F Koval
Jan 1, 2014·FEMS Microbiology Reviews·Brady F CressMattheos A G Koffas
Nov 25, 2014·Antibiotics·Kathryn L NawrockiShonna M McBride
Aug 1, 1994·FEMS Immunology and Medical Microbiology·J RodgersC Olliff
Mar 1, 1986·The Journal of Urology·J C NickelJ W Costerton

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