Influence of endodontic treatment on systemic oxidative stress

International Journal of Medical Sciences
Francesco InchingoloMarco Tatullo


An increased production of oxidizing species related to reactive oral diseases, such as chronic apical periodontitis, could have systemic implications such as an increase in cardiovascular morbidity. Based on this consideration, we conducted a prospective study to assess whether subjects affected by chronic periodontitis presented with higher values of oxidative stress than reference values before endodontic treatment, and whether endodontic treatment can reduce the oxidative imbalance and bring it back to normal in these subjects. The authors recruited 2 groups of patients from private studies and dental clinics: these patients were recruited randomly. The oxidative balance in both patients with chronic apical periodontitis (CAP) and healthy control patients was determined by measuring the oxidant status, using an identification of the reactive oxygen metabolites (d-ROMs) test, while the antioxidant status in these patients was determined using a biological antioxidant potential (BAP) test. Both these tests were carried on plasma samples taken from enrolled patients. Values were measured both before the endodontic treatment of the patients with chronic apical periodontitis, and 30 and 90 days after treatment, and compared to t...Continue Reading


Dec 9, 2015·Journal of Enzyme Inhibition and Medicinal Chemistry·Francesco MenichiniVincenzo Mastellone
Mar 24, 2017·International Endodontic Journal·J H MeurmanA Walls
Dec 27, 2018·Acta Odontologica Scandinavica·Paulo Henrique Braz-SilvaPeter Jonasson
Nov 23, 2017·Frontiers in Physiology·Patricia Hernández-RíosMarcela Hernández
Oct 27, 2018·Brazilian Oral Research·Luciano Tavares Angelo CintraJoão Eduardo Gomes-Filho


Apr 10, 2002·Clinical Chemistry and Laboratory Medicine : CCLM·GianMario GerardiLorenzo Diego Di
Apr 26, 2006·Journal of Cell Science·Carlos ZaragozaSantiago Lamas
Apr 10, 2009·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Carole Elbim, Gérard Lizard
Nov 26, 2009·Journal of Endodontics·James L GutmannRichard E Walton
May 13, 2011·Proteomics·Craig H SteevesStephen L Bearne

Related Concepts

Periapical Periodontitis
Antioxidant Effect
Oxidative Stress
Oxidative Stress Analysis
Chronic Apical Periodontitis
Obesity, Morbid

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