Influence of endoscopic papillary balloon dilation and endoscopic sphincterotomy on sphincter of oddi function: a randomized controlled trial

Endoscopy
M TakezawaK Saigenji

Abstract

Endoscopic papillary balloon dilation (EPBD) is assumed to have a theoretical advantage over endoscopic sphincterotomy (EST) in preserving sphincter of Oddi function because it does not involve cutting the biliary sphincter. Although attempts have been made to study the influence of EPBD and EST on sphincter of Oddi function, there is little agreement on this issue. In this study we used a method different from those described in previous reports to clarify whether EPBD or EST preserves sphincter of Oddi function better. 200 patients with bile duct stones who met the eligibility criteria were randomly assigned to EPBD (n = 104) or an EST (n = 96) group. Sphincter of Oddi function was estimated by measurement of the activity of pancreatic enzymes in the common bile duct (CBD). Pure bile was collected immediately before EPBD or EST, at 1 week and at 1 year after the procedure. We also statistically investigated 14 factors other than EPBD or EST that might have the potential to affect sphincter of Oddi function. There was no significant difference between the baseline characteristics of the EPBD and EST groups. A total of 91 patients (46 in the EPBD group and 45 in the EST group) remained in the trial. Pure bile was collected from...Continue Reading

Citations

Apr 9, 2005·Current Opinion in Gastroenterology·Ann Marie Joyce, Michael L Kochman
Jun 21, 2008·Journal of Gastroenterology and Hepatology·Pramod Kumar Garg
Sep 15, 2009·World Journal of Gastroenterology : WJG·Hyun Gun KimMoon Sung Lee
Apr 25, 2013·World Journal of Gastroenterology : WJG·Bai-Qing FuChun-Suo Zhou
Dec 24, 2013·World Journal of Gastroenterology : WJG·Seung Uk JeongMyung-Hwan Kim
Oct 9, 2009·Scandinavian Journal of Gastroenterology·Kjell-Arne UngAntal Bajor
Mar 24, 2007·The Journal of Medical Investigation : JMI·Yasunori SatoSusumu Ito
Sep 9, 2017·World Journal of Gastroenterology : WJG·Xiao-Dan XuChun-Fang Xu
Feb 13, 2020·Pancreas·Carolina Ogawa MatsubayashiEduardo Guimarães Hourneaux de Moura

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