Influence of endothelial nitric oxide on adrenergic contractile responses of human cerebral arteries

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
M AldasoroS Lluch

Abstract

The present study was designed to investigate the influence of the endothelium and that of the L-arginine pathway on the contractile responses of isolated human cerebral arteries to electrical field stimulation (EFS) and norepinephrine. Rings of human middle cerebral artery were obtained during autopsy of 19 patients who had died 3-8 h before. EFS (1-8 Hz) induced frequency-dependent contractions that were abolished by tetrodotoxin, prazosin, and guanethidine (all at 10(-6) M). The increases in tension were of greater magnitude in arteries denuded of endothelium. N(G)-monomethyl L-arginine (L-NMMA 10(-4) M) potentiated the contractile response to EFS in artery rings with endothelium but did not influence responses of endothelium-denuded arteries. L-arginine (10(-4) M) reversed the potentiating effects of L-NMMA on EFS-induced contractions. Norepinephrine induced concentration-dependent contractions, which were similar in arteries with and without endothelium or in arteries treated with L-NMMA. Indomethacin (3 x 10(-6) M) had no significant effect on the contractile response to EFS or on the inhibition by L-NMMA of acetylcholine-induced relaxation. These results suggest that the contractile response of human cerebral arteries to...Continue Reading

References

Nov 1, 1992·Stroke; a Journal of Cerebral Circulation·C Loeb
Nov 1, 1990·British Journal of Pharmacology·D D ReesS Moncada
May 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C González, C Estrada
Nov 20, 1990·European Journal of Pharmacology·G A GrayJ C Stoclet
Mar 1, 1990·British Journal of Pharmacology·E M de AguileraS Lluch
Aug 21, 1990·European Journal of Pharmacology·N P WiklundP Hedqvist
Dec 1, 1990·Stroke; a Journal of Cerebral Circulation·E Martín de AguileraS Lluch
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D D ReesS Moncada
May 1, 1988·Trends in Pharmacological Sciences·T F Luscher, P M Vanhoutte
Mar 1, 1973·Atherosclerosis·L A Rosen, T M Hollis
Jan 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K NozakiS H Snyder
Mar 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H OnoueN Nakamura

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Citations

Jan 6, 2007·Stroke; a Journal of Cerebral Circulation·Karin F HothRonald A Cohen
Jul 10, 2007·Ultrasound in Medicine & Biology·Janja Pretnar-OblakMarjan Zaletel
Apr 20, 2006·Diabetic Medicine : a Journal of the British Diabetic Association·F S NazirS J Cleland
May 9, 2007·American Journal of Hypertension·Martin AldasoroJosé M Vila
Nov 9, 2005·Cerebrovascular Diseases·Kennedy R Lees, Matthew R Walters
Jan 28, 1998·Stroke; a Journal of Cerebral Circulation·E ThorinA Bouthillier
Oct 8, 1999·Stroke; a Journal of Cerebral Circulation·G SegarraD A Pelligrino
Oct 11, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Peter TothZoltan I Ungvari
May 21, 1998·Journal of Cardiovascular Pharmacology·X BoG Burnstock
Feb 11, 1998·Physiological Reviews·F M Faraci, D D Heistad
Sep 4, 2015·World Journal of Gastroenterology : WJG·Paloma LluchPascual Medina

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