Influence of endotoxin on daytime sleep in humans.

Infection and Immunity
C KorthT Pollmächer

Abstract

Administration of endotoxin in the evening has been shown to transiently suppress rapid eye movement (REM) and to promote non-REM sleep in humans. In a single-blind placebo-controlled crossover design, we assessed the effects of Salmonella abortus equi endotoxin administered intravenously in the morning on the primary host response and on daytime sleep by use of a multiple napping protocol in healthy volunteers. The extent of the host response achieved by 0.8 ng of endotoxin per kg of body weight given at 0900 h was comparable to that previously reported to result from the administration of 0.4 ng/kg at 1900 h. However, sleep was only slightly influenced. Endotoxin reduced the amount of REM sleep and increased REM latency. Non-REM sleep amount in the first nap, although not significantly changed, correlated negatively with the individual peak levels of interleukin-6 (r = -0.73, P < 0.05). Subjective tiredness, sleep onset latency, total sleep time, and the amounts of slow-wave and non-REM sleep were not affected by endotoxin throughout the entire experiment. Spectral analysis of the electroencephalogram obtained during non-REM sleep yielded no condition differences. We conclude that endotoxin administration in the morning to he...Continue Reading

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Citations

Mar 28, 2001·Annals of the New York Academy of Sciences·T PollmächerJ Mullington
May 10, 2002·Annals of the New York Academy of Sciences·J M MullingtonT Pollmächer
Oct 23, 1997·Critical Care Medicine·V PollardD L Traber
Nov 11, 2016·PloS One·Gustav NilsonneMichael Ingre
Apr 13, 1999·The American Journal of Physiology·A SchuldT Pollmächer
Apr 6, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J MullingtonT Pollmächer
Aug 12, 2009·Neuroscience and Biobehavioral Reviews·Nicole DellaGioia, Jonas Hannestad

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