PMID: 18200398Jan 18, 2008Paper

Influence of epipregnanolone on the modulation of rapid tolerance to ethanol by neurosteroids

Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina
Adriana Dias Elpo Barbosa, Gina Struffaldi Morato

Abstract

The objective of the present study was to investigate the effect of epipregnanolone on the influence of neurosteroids on the development of rapid tolerance to the motor impairing and hypothermic effects of ethanol. Experiment 1: on Day 1 groups of mice were pretreated with saline or with epipregnanolone. After 30 min each group was further divided in subgroups that received ethanol or saline. Thirty, 60 and 90 min after the injections the animals were tested on the rota-rod or the body temperature was measured. On Day 2 all groups received ethanol and a similar procedure was followed to evaluate rapid tolerance. Experiment 2 and 3: On Day 1 groups of mice were treated with epipregnanolone and after 15 min each group was divided into three groups in order to receive pregnenolone sulfate, dehydroepiandrosterone sulfate or saline. Thirty minutes later, each group was further divided into two subgroups in order to receive ethanol or saline, respectively, and 30, 60 and 90 min later the animals were tested as in the experiment 1. On Day 2 all groups received ethanol and a similar procedure was followed to evaluate rapid tolerance. Pretreatment with epipregnanolone (0.10-0.30 mg/kg) significantly blocked the development of tolerance ...Continue Reading

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Citations

Feb 26, 2021·Pharmacology, Biochemistry, and Behavior·Sophie K ElvigLeandro F Vendruscolo

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