Influence of epoch length on measurement of dynamic functional connectivity in wakefulness and behavioural validation in sleep

NeuroImage
Rebecca S WilsonAndrew P Bagshaw

Abstract

Conventional functional connectivity (FC) analysis of fMRI data derives a single measurement from the entire scan, generally several minutes in duration, which neglects the brain's dynamic behaviour and potentially loses important temporal information. Short-interval dynamic FC is an attractive proposition if methodological issues can be resolved and the approach validated. This was addressed in two ways; firstly we assessed FC of the posterior cingulate cortex (PCC) node of the default mode network (DMN) using differing temporal intervals (8s to 5min) in the waking-resting state. We found that 30-second intervals and longer produce spatially similar correlation topography compared to 15-minute static FC measurements, while providing increased temporal information about changes in FC that were consistent across interval lengths. Secondly, we used NREM sleep as a behavioural validation for the use of 30-second temporal intervals due to the known fMRI FC changes with sleep stage that have been observed in previous studies using intervals of several minutes. We found significant decreases in DMN FC with sleep depth which were most pronounced during stage N2 and N3. Additionally, both the proportion of time with strong PCC-DMN conn...Continue Reading

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Citations

Apr 22, 2015·NeuroImage·Joanne R HaleAndrew P Bagshaw
Jan 20, 2019·Human Brain Mapping·Victor M VergaraVince D Calhoun
Aug 20, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Andrea N Goldstein-PiekarskiLeanne M Williams
Jul 30, 2019·Frontiers in Neuroscience·Muhammad E H ChowdhuryRichard Bowtell
Apr 19, 2017·Brain Structure & Function·Han ZhangAnqi Qiu
Feb 8, 2020·NeuroImage. Clinical·George GiffordPhilip McGuire
Oct 17, 2020·Human Brain Mapping·Weixiong JiangDinggang Shen
May 1, 2021·Journal of Neurology·Julia SchumacherAlan J Thomas
Jan 31, 2019·Psychotherapy and Psychosomatics·Zhiying ZhaoBenjamin Becker

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