Abstract
The endoplasmic reticulum aminopeptidases (ERAPs), ERAP1 and ERAP2, makes a role in shaping the HLA class I peptidome by trimming peptides to the optimal size in MHC-class I-mediated antigen presentation and educating the immune system to differentiate between self-derived and foreign antigens. Association studies have shown that genetic variations in ERAP1 and ERAP2 genes increase susceptibility to autoimmune diseases, infectious diseases, and cancers. Both ERAP1 and ERAP2 genes exhibit diverse polymorphisms in different populations, which may influence their susceptibly to the aforementioned diseases. In this article, we review the distribution of ERAP1 and ERAP2 gene polymorphisms in various populations; discuss the risk or protective influence of these gene polymorphisms in autoimmune diseases, infectious diseases, and cancers; and highlight how ERAP genetic variations can influence disease associations.
Citations
Nov 16, 2019·European Journal of Immunology·Kathrin Textoris-TaubeUlrike Seifert
Mar 19, 2020·Cells·Irma SaulleMara Biasin
Aug 28, 2020·Cells·Irma SaulleMara Biasin
Aug 15, 2020·Frontiers in Immunology·Fabiana PaladiniRosa Sorrentino
Aug 23, 2020·International Journal of Molecular Sciences·Ombretta MelaiuDoriana Fruci
Feb 6, 2020·Biological & Pharmaceutical Bulletin·Masafumi TsujimotoYoshikuni Goto
Jul 1, 2020·BioMed Research International·Guolin WuYa Guo
Dec 1, 2020·Frontiers in Genetics·Shuqiong ZhangLi Shi
Jan 7, 2021·Immunological Investigations·Shutao GaoWeibin Sheng
Feb 12, 2021·International Journal of Molecular Sciences·Silvia D'AmicoDoriana Fruci
Mar 9, 2021·Frontiers in Genetics·Jingzhan ZhangXiaojing Kang
Jun 22, 2021·Frontiers in Immunology·Andrzej WiśniewskiPiotr Kuśnierczyk
Jul 27, 2021·Proteomics·Sebastian Joyce, Nicola Ternette
Aug 17, 2021·BioMed Research International·Xiujuan Wu, Zongfeng Zhao
Nov 3, 2021·Investigative Ophthalmology & Visual Science·Sahar GelfmanUNKNOWN Regeneron Genetics Center