PMID: 11338054May 8, 2001Paper

Influence of errors in sampling time and in activity measurement on the single sample clearance determination

Nuclear Medicine Communications
C De SadeleerH R Ham

Abstract

Plasma clearance rate of 51Cr-EDTA estimated by using one blood sample is commonly used for the calculation of glomerular filtration rate. To estimate the error on single-sample clearance determination induced by errors in sampling time and activity measurement, and to compare it with the error observed on the clearance determination obtained using the slope-intercept method. Forty-five adult patients were chosen from a data base of 51Cr-EDTA plasma clearance values determined by using two blood samples taken around 2 and 4 h. Patients were selected in such a way as to include clearances from 30 ml.min-1 to 155 ml.min-1, with steps of 3 ml.min-1. Based on the slope and the intercept of the slope with the y-axis, the plasma concentration at exactly 2 and 4 h was determined. Normally distributed random errors were then introduced in the sampling time (SD of 0, 1 and 2 min) as well as in the activity measurement (SD of 0, 1, 2 and 5%). Then, clearance was calculated using two single-sample methods (i.e. the algorithms of Groth and Tauxe), and the slope-intercept method, which requires two blood samples. For each setting, the simulation was repeated 200 times. The effects on clearance of a random error on the time sampling and/or t...Continue Reading

References

Jan 1, 1992·European Journal of Nuclear Medicine·W S Watson

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Citations

May 11, 2010·Journal of Feline Medicine and Surgery·Eva VandermeulenKathelijne Y Peremans
Jul 9, 2013·Scandinavian Journal of Clinical and Laboratory Investigation·Ulrik L HenriksenJens H Henriksen
Apr 23, 2014·Clinical Physiology and Functional Imaging·Ulrik L Henriksen, Jens H Henriksen
Dec 17, 2005·Seminars in Nuclear Medicine·Amy Piepsz, Hamphrey R Ham
Apr 22, 2016·Nuclear Medicine Communications·Helena McMeekinMaria Burniston
Oct 22, 2019·Nuclear Medicine Communications·Helena McMeekinMaria Burniston

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