Influence of erythropoietin treatment on follitropin and lutropin response to luliberin and plasma testosterone levels in haemodialyzed patients

Nephron
F KokotM Klin

Abstract

Plasma levels of follitropin (FSH), lutropin (LH) and testosterone (TE) were estimated in 5 anaemic haemodialyzed patients before and after 3 months of erythropoietin treatment (EPO group), in 5 male haemodialyzed patients with a haematocrit value of 33% (which was of the same magnitude as the post-treatment haematocrit value in the EPO group) and in 15 male healthy subjects. After EPO treatment, haematocrit values rose from 23.0 +/- 0.9 to 34.6 +/- 0.75%. EPO treatment induced a significant suppression of basal plasma FSH and LH levels, while plasma TE levels slightly increased. After EPO treatment, the response of plasma FSH and LH to luliberin administration was significantly reduced. As the endocrine profile of EPO-treated patients differed from that of haemodialyzed patients showing a similar haematocrit value, it seems that EPO-induced hormonal changes are not or not only related to improvement of anaemia. Normalization of the pituitary-gonadal feedback in EPO treatment seems to participate in the pathogenesis of improved sexual activity in these patients.

Citations

Nov 16, 2001·Journal of the American College of Surgeons·F F ChouS M Sheen-Chen
Feb 13, 2001·International Journal of Urology : Official Journal of the Japanese Urological Association·K HayakawaM Hata
Mar 1, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Michael DeLongYeong-Hau H Lien
May 1, 1995·Psychosomatics·T M Brown, R L Brown
Mar 17, 2004·Fertility and Sterility·Kumiko TemmaYuji Murata
May 20, 1999·Baillière's Clinical Endocrinology and Metabolism·D J Handelsman, P Y Liu

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