PMID: 19942988Nov 28, 2009Paper

Influence of estradiol and triiodothyronine on breast cancer cell lines proliferation and expression of estrogen and thyroid hormone receptors

Arquivos brasileiros de endocrinologia e metabologia
Sílvia Helena CestariCélia Regina Nogueira

Abstract

To better understand the estrogen (E2) agonist action of triiodothyronine (T3) the effects of these hormones on ER negative MDA-MB-231 breast cancer cells were compared with those on S30, a clone of MDA-MB-231 stably transfected with ERalpha cDNA, in terms of proliferation and modulation of hormone receptors. Growth experiments showed that MDA-MB-231 was not modulated by any hormone or tamoxifen (TAM). Treatment with E2, 10(-8)M or 10(-9)M had little effect on S30 proliferation. T3 at 10(-8)M significantly inhibited proliferation. This effect was not reverted by TAM. Treatments with 10(-8)M concentration of E2 or T3 reduced ERalpha gene expression in S30, an effect partially blocked by association with TAM, with no effect on TR expression. These results suggest that, in S30, 10(-8)M T3 has a similar action to E2 relative to ERalpha gene modulation. Such results emphasize the need of determining T3 levels, before the introduction of antiestrogenic forms of treatment in breast cancer patients.

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Citations

Apr 21, 2016·Life Sciences·Fernanda Cristina Fontes MorettoCélia Regina Nogueira
Dec 30, 2014·Breast Cancer Research and Treatment·Katarzyna J JerzakAnita Bane
Aug 13, 2014·World Journal of Clinical Oncology·Maria Teresa De SibioCélia Regina Nogueira
Feb 15, 2018·Hormones & Cancer·Aleck HercbergsPaul J Davis
Nov 8, 2018·Endocrine-related Cancer·Iuri Martin GoemannAna Luiza Maia
Jul 14, 2012·Arquivos brasileiros de endocrinologia e metabologia·Sandro José CondeCélia Regina Nogueira
Mar 1, 2019·Frontiers in Endocrinology·Eilon KrashinOsnat Ashur-Fabian
Aug 11, 2018·Breast Cancer Research : BCR·Carolina Ortega-OlveraGabriela Torres-Mejía
Jan 23, 2021·International Journal of Molecular Sciences·Alaleh Zati ZehniTheresa Vilsmaier

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