Influence of estrogen-progesterone combinations on gonadotropin secretion in castrate female rats(1).

Endocrinology
J C McPhersonV B Mahesh

Abstract

In order to study the effect of progesterone in modulating the secretion of gonadotropins, various doses of progesterone were administered to castrated immature and mature female rats. Progesterone did not prevent the postcastration rise of FSH and LH in these animals. Various amounts of progesterone were then administered to castrated rats that were treated with a constant low dose of estradiol. In animals given doses of estradiol that were able to decrease serum FSH and LH below castrate levels, but not to prevent the post-castration rise, the effect of progesterone was dose-dependent. A very low dose of progesterone lowered serum gonadotropins, an intermediate dose brought about an increase in secretion, and high doses were suppressive. The modifying action of progesterone appears to be dependent upon the level of estrogen, the dose of progesterone, and the time of administration.

Citations

May 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D P DesimoneN H Bell
Jan 1, 1983·Virchows Archiv. A, Pathological Anatomy and Histopathology·M AnnikoP Eneroth
Jan 1, 1987·Journal of Steroid Biochemistry·V B Mahesh, T G Muldoon
Jan 9, 1992·European Journal of Obstetrics, Gynecology, and Reproductive Biology·C Castelo-BrancoJ González-Merlo
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·V B Mahesh
Jun 1, 1989·Molecular and Cellular Endocrinology·E J SmanikV B Mahesh
Sep 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·C Putnam-RobertsV B Mahesh
Jun 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·L A Lesoon, V B Mahesh
Jun 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·D W Brann, V B Mahesh
Jan 1, 1996·The Journal of Steroid Biochemistry and Molecular Biology·V B MaheshL B Hendry
Jun 20, 2003·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Christiane AttekeThierry Bailhache
Oct 27, 2011·American Journal of Physiology. Endocrinology and Metabolism·Virendra B Mahesh
Aug 31, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·A M BrownP Callahan
Sep 1, 1980·Archives of Andrology·E S Hafez
Sep 21, 2010·Contraception·Alison B EdelmanFrank Z Stanczyk
Sep 1, 1993·Maturitas·C Castelo-BrancoJ González-Merlo
Mar 22, 2001·Frontiers in Neuroendocrinology·J E LevineM Szabo
Dec 1, 1988·Asia-Oceania Journal of Obstetrics and Gynaecology·S ArakawaK Arai
Oct 14, 2020·Brain Research·Procópio Cleber Gama de Barcellos FilhoCelso Rodrigues Franci

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