Influence of ethanol and acetaldehyde on electro-mechanical coupling of skeletal muscle fibers

Acta Physiologica Scandinavica
A R Khan

Abstract

The effects of ethanol were studied on the time course of the isometric twitch and tetanus of isolated semitendinosus muscle fibers of Rana temporaria (at 2.8-4.5 degrees C). Ethanol in concentrations between (0.1-0.4 M) suppressed the isometric twitch without significantly affecting the tetanic tension amplitude. A further increase in ethanol concentration (0.5 M) depressed the tetanic tension as well. The maximum rate of force development both of twitch and tetanus was reduced. These changes were fully reversible when ethanol was removed from the bathing fluid. In presence of ethanol there was a reduction, although not statistically significant, in the resting membrane potential and in the maximum rate of rise of the action potential. The overshoot and the maximum rate of fall of the action potential were significantly lowered leading to a prolongation of the duration of the action potential. Acetaldehyde in relatively low concentrations (0.9-1.8 mM) caused marked potentiation of the twitch without significantly affecting the tetanic amplitude. These changes were, to a great extent, reversible. Higher concentrations (18 mM) of acetaldehyde reduced both the twitch and the tetanic tension and these effects were not reversible o...Continue Reading

References

Apr 1, 1977·The Journal of Pharmacology and Experimental Therapeutics·K G Morgan, S H Bryant
Apr 1, 1972·The Journal of General Physiology·S R TaylorA Sandow
Jan 21, 1972·Science·S K Song, E Rubin
Jan 1, 1966·Pflügers Archiv für die gesamte Physiologie des Menschen und der Tiere·K A EdmanE Nilsson
Jul 1, 1962·The American Journal of Physiology·A L GIMENOJ L WEBB
Dec 11, 1964·Science·A SANDOW, H PREISER

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Citations

Jun 1, 1995·Alcoholism, Clinical and Experimental Research·M PagalaD Grob
Oct 13, 2000·American Journal of Physiology. Cell Physiology·T ObaM Yamaguchi
Apr 13, 2004·American Journal of Physiology. Cell Physiology·Toshiharu Oba, Yoshitaka Maeno
Nov 1, 1983·The American Journal of Physiology·L M Kerr, N Sperelakis

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