PMID: 11932957Apr 5, 2002Paper

Influence of ethanol on neonatal cerebellum of BDNF gene-deleted animals: analyses of effects on Purkinje cells, apoptosis-related proteins, and endogenous antioxidants

Journal of Neurobiology
Marieta Barrow HeatonJoanne Mayer

Abstract

The sensitivity of the developing central nervous system (CNS) to the deleterious effects of ethanol has been well documented, with exposure leading to a wide array of CNS abnormalities. Certain CNS regions are susceptible to ethanol during well-defined critical periods. In the neonatal rodent cerebellum, a profound loss of Purkinje cells is found when ethanol is administered early in the postnatal period [on postnatal days 4 or 5 (P4-5)], while this neuronal population is much less vulnerable to similar ethanol insult slightly later in the postnatal period (P7-9). Prior studies have shown that neurotrophic factors (NTFs) can be altered by ethanol exposure, and both in vitro and in vivo studies have provided evidence that such substances have the potential to protect against ethanol neurotoxicity. In the present study, it was hypothesized that depletion of an NTF shown to be important to cerebellar development would exacerbate ethanol-related effects within this region, when administration was confined to a normally ethanol-resistant ontogenetic period. For this study, brain-derived neurotrophic factor (BDNF) gene-deleted ("knockout") and wild-type mice were exposed to ethanol via vapor inhalation or to control conditions durin...Continue Reading

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Citations

Oct 22, 2003·Progress in Neurobiology·Justyna R Sarna, Richard Hawkes
May 26, 2004·Brain Research. Developmental Brain Research·Marieta Barrow HeatonKendra I Siler-Marsiglio
May 10, 2005·Birth Defects Research. Part A, Clinical and Molecular Teratology·Pedro MeloMaria Amélia Tavares
Mar 24, 2006·Journal of Neuroscience Research·D L GruolC E Gullette
Aug 2, 2003·The Journal of Pharmacology and Experimental Therapeutics·Julie C LauterbornChristine M Gall

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