Influence of exercise intensity and duration on functional and biochemical perturbations in the human heart

The Journal of Physiology
Glenn M StewartSurendran Sabapathy

Abstract

Strenuous endurance exercise induces transient functional and biochemical cardiac perturbations that persist for 24-48 h. The magnitude and time-course of exercise-induced reductions in ventricular function and increases in cardiac injury markers are influenced by the intensity and duration of exercise. In a human experimental model, exercise-induced reductions in ventricular strain and increases in cardiac troponin are greater, and persist for longer, when exercise is performed within the heavy- compared to moderate-intensity exercise domain, despite matching for total mechanical work. The results of the present study help us better understand the dose-response relationship between endurance exercise and acute cardiac stress/injury, a finding that has implications for the prescription of day-to-day endurance exercise regimes. Strenuous endurance exercise induces transient cardiac perturbations with ambiguous health outcomes. The present study investigated the magnitude and time-course of exercise-induced functional and biochemical cardiac perturbations by manipulating the exercise intensity-duration matrix. Echocardiograph-derived left (LV) and right (RV) ventricular global longitudinal strain (GLS), and serum high-sensitivity...Continue Reading

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Citations

Jun 2, 2016·The Journal of Physiology·Glenn M StewartSurendran Sabapathy
Jun 2, 2016·The Journal of Physiology·Guido Claessen, Andre La Gerche
Jul 6, 2016·European Heart Journal Cardiovascular Imaging·Glenn M StewartSurendran Sabapathy
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Dec 16, 2016·The Journal of Physiology·Emily VecchiarelliKatharine D Currie
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Mar 17, 2020·Medicine and Science in Sports and Exercise·Glenn M StewartSurendran Sabapathy
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Aug 31, 2021·Journal of the American Heart Association·Magnus Bjørkavoll-BergsethStein Ørn

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