Influence of exercise on nitroglycerin plasma concentrations after transdermal application

British Journal of Clinical Pharmacology
R A LefebvreJ P Dubois

Abstract

Nitroglycerin plasma concentrations following transdermal application were measured in nine healthy subjects during supine rest position or during supine rest interrupted by sitting or exercising for 20 min. Sitting led to almost doubling of the average plasma concentrations (0.31 ng ml-1 before sitting, 0.55 ng ml-1 at the end of the sitting period), but exercise was accompanied by a much more marked increase in average plasma concentrations, which reached its maximum 5 min after ending exercise (0.22 ng ml-1 before exercise, 1.26 ng ml-1 5 min after the exercise period). Changes of bioavailability as well as of systemic clearance might be involved in the exercise-induced increase in plasma nitroglycerin concentrations.

References

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Citations

Oct 1, 1994·Cardiovascular Drugs and Therapy·M G Bogaert
Jan 1, 1992·European Journal of Clinical Pharmacology·T O KlemsdalJ E Bredesen
Jan 14, 1999·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·P ClarysV Préat
Feb 27, 2003·Clinical Pharmacokinetics·Satoru Hashimoto, Atsuko Kobayashi
Mar 15, 2011·Sports Medicine·Thomas L Lenz, Nicole Gillespie
Jun 13, 2014·Expert Opinion on Drug Safety·Anette LampertHanna M Seidling
Jan 20, 2011·Expert Opinion on Drug Metabolism & Toxicology·Thomas L Lenz
Jan 24, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yasser ShahzadJeanetta du Plessis
Apr 18, 2015·Environmental Research·Esther MarcoManolis Kogevinas

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