Influence of exogenous atrial natriuretic peptide on the pituitary-adrenal response to corticotropin-releasing hormone and vasopressin in healthy men

The Journal of Clinical Endocrinology and Metabolism
C BierwolfHorst Lorenz Fehm

Abstract

Atrial natriuretic peptide (ANP) has been considered a potential candidate participating in the inhibitory control of pituitary-adrenal secretory activity. Here, we investigated the influence of ANP, infused at two different doses and over infusion intervals of two different durations, on the release of ACTH and cortisol after stimulation with CRH and with combined administration of CRH and vasopressin (VP). In young healthy men, three experiments were conducted. In Exp I, ACTH/cortisol secretory responses to CRH (50 microg) were examined during and after a 45-min period of ANP infusion at a rate of 4.4 microg/min (starting 15 min before CRH injection). In Exp II, ACTH/cortisol secretory responses to CRH (50 microg) were examined during and after a 90-min infusion period of ANP administered at rates of 4.4 and 8.8 microg/min. In Exp III, ANP was infused at a rate of 4.4 microg/min over 90 min, but instead of CRH, a combined administration of CRH (50 microg) and VP (0.5 IU infused within 5 min) was employed to stimulate ACTH/cortisol release. ANP diminished pituitary-adrenal secretory responses within the first hour after stimulation with exogenous secretagogues. Thereafter, the effect of ANP turned in the opposite direction, wi...Continue Reading

References

Jan 1, 1991·Neuroendocrinology·L Y MaD M Zhang
Dec 1, 1987·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·E Späth-SchwalbeE F Pfeiffer
Aug 1, 1986·The Journal of Endocrinology·M OhashiH Matsuo
Jul 1, 1970·Psychosomatic Medicine·J W Mason
Nov 1, 1993·The Journal of Clinical Endocrinology and Metabolism·E Späth-SchwalbeH L Fehm
Apr 29, 1993·Regulatory Peptides·M Abramow, E Cogan
Apr 29, 1993·Regulatory Peptides·A G Robinson, M D Fitzsimmons
Jun 1, 1997·Journal of Neuroendocrinology·C BierwolfH L Fehm

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