Influence of experimental protocol on response rate and repeatability of mechanical threshold testing in dogs

The Veterinary Journal
L K HarrisH R Whay

Abstract

Mechanical threshold (MT) testing is widely used to measure nociceptive thresholds. However, there has been little research into factors that contribute to the response rate and repeatability (collectively termed 'efficacy') of MT testing protocols. The aim of this study was to investigate whether the efficacy of a protocol using a hand-held algometer to measure MTs (N) in healthy dogs (n = 12) was affected by varying (1) the area over which force was applied (tip diameter), (2) rate of force application, (3) position of dog during testing, and (4) anatomical site of testing. The effect of these factors on MT and the impact of individual dog effects on both efficacy and MT were also investigated. Overall, 3175/3888 tests (82%) resulted in a measurable response. The response rate was reduced by using wider tip diameters, testing at the tibia, and testing when the dog was lying down (compared to sitting upright). Wider tips were associated with higher, more variable MTs (mean ± standard deviation) with values of 4.18 ± 2.55 N for 2 mm diameter tips, 5.54 ± 3.33 for those of 4 mm, and 7.59 ± 4.73 for 8 mm tips. Individual dog effects had the most significant impact on efficacy and MT. The findings indicate that tip diameter, dog p...Continue Reading

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Citations

Nov 16, 2016·Animals : an Open Access Journal From MDPI·Craig Johnson
Mar 31, 2017·BMC Veterinary Research·Una Pongratz, Theresia Licka
Sep 30, 2019·The Veterinary Record·Morgane Schambourg, Polly M Taylor
May 29, 2020·Journal of Veterinary Internal Medicine·Natalia ZidanNatasha Olby
May 23, 2017·Veterinary Anaesthesia and Analgesia·David KnazovickyB Duncan X Lascelles
Dec 10, 2017·Physiology & Behavior·Alessandro MirraDaniela Casoni

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