Influence of exposure concentration or dose on the distribution of particulate material in rat and human lungs

Environmental Health Perspectives
K J NikulaF F Hahn

Abstract

Differences among species in the anatomic sites of particle retention could influence responses to inhaled particles. In this study, we used morphometric techniques to examine the influence of exposure concentration on particle retention in histologic sections from rats and humans. The rats had been exposed for 24 months to diesel exhaust at 0.35, 3.5, or 7.0 mg soot/m(3). The human subjects were nonsmokers who did not work as miners, nonsmoking coal miners who worked under the current standard of 2 mg dust/m(3) for 10-20 years (mean = 14 years), and nonsmoking coal miners who worked under the former standard of < 10 mg dust/m(3) for 33-50 years (mean = 40 years). The distribution of retained particles within the lung compartments was markedly different between species. In all three groups of rats, 82-85% of the retained particulate material was located in the alveolar and alveolar duct lumens, primarily in macrophages. In humans, 57, 68, and 91% of the retained particulate material was located in the interstitium of the lung in the non-miners, coal miners under the current standard, and coal miners under the former standard, respectively. These results show that chronically inhaled diesel soot is retained predominantly in the ...Continue Reading

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Citations

Mar 22, 2014·International Journal of Molecular Sciences·Eleonore Fröhlich, Sharareh Salar-Behzadi
Jan 5, 2011·The Annals of Occupational Hygiene·Christian Strupp
Jul 14, 2010·Environmental Monitoring and Assessment·Huma SiddiquiIqbal Ahmad
Apr 12, 2015·The Science of the Total Environment·Jurgen BuekersAdriana R Oller
Jan 16, 2010·Regulatory Toxicology and Pharmacology : RTP·Jürgen Pauluhn
Mar 12, 2009·Regulatory Toxicology and Pharmacology : RTP·P A ValbergR J McCunney
Nov 10, 2015·Journal of Occupational and Environmental Hygiene·Eileen D KuempelAnnie M Jarabek
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Dec 13, 2006·Journal of Occupational and Environmental Medicine·David B Warheit, Steven R Frame
Mar 10, 2020·Inhalation Toxicology·Kevin E Driscoll, Paul J A Borm
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Aug 10, 2018·Toxicology Research·Frank S BierkandtAndreas Luch
Apr 15, 2020·Annual Review of Pharmacology and Toxicology·Hedwig M BraakhuisFlemming R Cassee

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