Influence of External NaCl Salt on Membrane Rigidity of Neutral DOPC Vesicles.

Langmuir : the ACS Journal of Surfaces and Colloids
Judith U De MelGerald J Schneider

Abstract

Sodium chloride (NaCl) is a very common molecule in biotic and abiotic aqueous environments. In both cases, variation of ionic strength is inevitable. In addition to the osmotic variation posed by such perturbations, the question of whether the interactions of monovalent ions Na+ and Cl-, especially with the neutral head groups of phospholipid membranes are impactful enough to change the membrane rigidity, is still not entirely understood. We investigated the dynamics of 1,2-di-(octadecenoyl)-sn-glycero-3-phosphocholine (DOPC) vesicles with zwitterionic neutral head groups in the fluid phase with increasing external salt concentration. At higher salt concentrations, we observe an increase in bending rigidity from neutron spin echo (NSE) spectroscopy and an increase in bilayer thickness from small-angle X-ray scattering (SAXS). We compared different models to distinguish membrane undulations, lipid tail motions, and the translational diffusion of the vesicles. All of the models indicate an increase in bending rigidity by a factor of 1.3-3.6. We demonstrate that even down to t > 10 ns and for Q > 0.07 Å-1, the observed NSE relaxation spectra are influenced by translational diffusion of the vesicles. For t < 5 ns, the lipid tail m...Continue Reading

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Citations

Feb 12, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Judith U De MelGerald J Schneider
Oct 11, 2020·Chemistry and Physics of Lipids·Micholas Dean Smith, Jeremy C Smith
Apr 29, 2021·Soft Matter·Rasangi M PereraGerald J Schneider
Jul 9, 2021·Soft Matter·Sudipta Gupta, Rana Ashkar
Jul 31, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Judith U De MelGerald J Schneider
Oct 27, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·J Tucker AndrewsPeter J N Kett

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