PMID: 6967117Jun 15, 1980Paper

Influence of extracellular Cl concentration on Cl transport across isolated skin of Rana pipiens

The Journal of Membrane Biology
T U BiberT L Mullen

Abstract

The effect of changes in Cl concentration in the external and/or serosal bath on Cl transport across short-circuited frog skin was studied by measurements of transepithelial Cl influx (JCl13) and efflux (JCl31), short-circuit current, transepithelial potential, and conductance (Gm). JCl13 as well as JCl31 were found to have a saturating component and a component which is apparently linear with Cl concentration. The linear component of JCl31 appears only upon addition of Cl to external medium, and about 3/4 of this component does not contribute to Gm. The saturating component of JCl31 is only 5% of total JCl31 with 115 mM Cl in the serosal medium. Replacement of 115 mM Cl- in external medium by SO4=, NO3-, HCO-3 or I- results in 87-97% reduction of JCl31, whereas replacement with Br- has no effect. As external Cl concentration is raised in steps from 2 to 115 mM, JCl13 and JCl31 increase by the same amount but JCl13 is persistently 0.15 mu eq/cm2hr larger than JCl31. These results indicate that at least 3/4 of linear components of JCl13 and JCl31 proceed via an exchange diffusion mechanism which seems to be located at the outer cell border. The saturating component of JCl13 is involved in active Cl transport in an inward directi...Continue Reading

References

Jan 1, 1978·The Journal of Membrane Biology·P Kristensen
Oct 1, 1976·The American Journal of Physiology·T U Biber, T L Mullen
Jan 1, 1978·The Journal of Membrane Biology·C L Voûte, W Meier
Jul 1, 1979·The Journal of General Physiology·S I HelmanR S Fisher
Jan 1, 1977·The American Journal of Physiology·T U Biber, T L Mullen
Sep 1, 1975·The American Journal of Physiology·R H AlvaradoT L Mullen
Sep 30, 1976·Pflügers Archiv : European journal of physiology·W Nagel
Dec 1, 1976·The American Journal of Physiology·L J Cruz, T U Biber
Jul 1, 1970·The Journal of General Physiology·T U Biber, P F Curran
Jan 1, 1980·The Journal of Membrane Biology·T U Biber, T L Mullen
Nov 1, 1963·The Journal of General Physiology·J A ZADUNAISKYD J CHIARANDINI
Nov 1, 1964·The American Journal of Physiology·J A ZADUNAISKY, F W DEFISCH

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Citations

Jan 1, 1984·The Journal of Membrane Biology·J W Hanrahan, J E Phillips
Jan 1, 1982·The Journal of Membrane Biology·M M Civan, R J Bookman
Jan 1, 1981·The Journal of Membrane Biology·W NagelW M Armstrong

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