Influence of farnesyl transferase inhibitor treatment on epidermal growth factor receptor status

Nuclear Medicine and Biology
Bart CornelissenGuido Slegers

Abstract

The radiolabelled growth factor [(123/125)I] I-hEGF is evaluated in vitro and in vivo to monitor the acute effects on the EGFR of R115777, a farnesyl transferase inhibitor (FTI). Upregulation of the EGFR after incubation with R115777 correlated linearly with FTI induced acute growth inhibition. Receptor mediated [125I] I-hEGF internalization decreased following R115777 treatment. Preliminary data suggest that the net in vivo effect is a decrease of [123I] I-hEGF uptake in the tumour. These findings suggest the possible use of radioiodinated hEGF as a radiodiagnosticum to investigate EGFR status changes as a predictor for eventual FTI chemotherapy outcome in vivo.

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Citations

Feb 1, 2011·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Eutimio Gustavo Fernández NúñezRoberto Pasqualini
Jun 29, 2005·Nuclear Medicine and Biology·Bart CornelissenGuido Slegers
Apr 19, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Bart CornelissenKatherine A Vallis

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