Influence of fish oil supplementation on in vivo and in vitro oxidation resistance of low-density lipoprotein in type 2 diabetes

European Journal of Clinical Nutrition
H PedersenPeter Marckmann

Abstract

Fish oil supplement has been proposed as a non-pharmacological strategy to correct the atherogenic lipid profile associated with type 2 diabetes mellitus. However, fish oil may have deleterious effects on lipid peroxidation and glycemic control. In this study, 44 type 2 diabetic patients were randomized to vitamin E standardized (53.6 mg/day) supplementation (capsules) with 4 g daily of either fish oil (n=23) or corn oil (n=21) for 8 weeks preceded by a 4 week run-in period of corn oil supplementation. LDL was isolated by density gradient ultracentrifugation and oxidized in vitro with Cu(2+). As a marker of in vivo oxidation malondialdehyde concentration in LDL (LDL-MDA) was measured. Fish oil reduced both mean lag time (before, 57.8; after, 48.8 min, P<0.001) and mean propagation rate (before, 0.018 DeltaOD/min; after, 0.015 DeltaOD/min, P<0.001), whereas corn oil had no influence on lag time and propagation rate. The changes in lag time and propagation rate differed significantly between fish oil and corn oil treatment. LDL-MDA changes differed borderline significantly between groups (FO, 110.4 pmol/mg protein; CO, 6.7 pmol/mg protein; P=0.057). Fish oil supplementation had no influence on glycemic control as assessed from Hb...Continue Reading

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Citations

Oct 19, 2006·Current Atherosclerosis Reports·Pietro Galassetti, Andria Pontello
Mar 5, 2005·Journal of the American Dietetic Association·Joyce A Nettleton, Robert Katz
Feb 13, 2009·The British Journal of Nutrition·Santiago Navas-CarreteroM Pilar Vaquero
Jul 20, 2006·Annual Review of Nutrition·Jay Whelan, Cheryl Rust
Mar 9, 2010·Prostaglandins, Leukotrienes, and Essential Fatty Acids·T Seppänen-LaaksoR Hiltunen
Sep 28, 2006·American Journal of Physiology. Endocrinology and Metabolism·Christian WadsackGernot Desoye
Feb 7, 2008·The Cochrane Database of Systematic Reviews·J HartwegA Farmer
Jul 9, 2005·The American Journal of Clinical Nutrition·Inar A CastroPatricia Sinnecker
Jul 5, 2017·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·S AbuMweisL Agraib
May 17, 2019·Nutrients·Vibeke H Telle-HansenMari C W Myhrstad

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