PMID: 11932962Apr 5, 2002Paper

Influence of fluconazole on the pharmacokinetics of omeprazole in healthy volunteers

Biopharmaceutics & Drug Disposition
Byoung C KangWan G Shin

Abstract

Influence of fluconazole on the pharmacokinetics of omeprazole was evaluated by single oral administration of omeprazole capsule 20 mg (control group), or single oral administration of fluconazole capsule, 100 mg, and omeprazole, 20 mg, after 4 days of daily oral administration of fluconazole, 100 mg (treated group), to 18 healthy male volunteers. Omeprazole is extensively metabolized in the liver through 5-hydroxylation and sulfoxidation reactions catalyzed predominantly by CYP2C19 and CYP3A4, respectively. Fluconazole is a potent competitive inhibitor of CYP2C19 and a weak inhibitor of CYP3A4. In treated group, the area under the plasma concentration-time curve of omeprazole from time zero to time infinity (AUC) was significantly greater (3090 vs 491 ng h/ml), terminal half-life of omeprazole was significantly longer (2.59 vs 0.85 h), and peak plasma concentration of omeprazole (C(max)) was significantly higher (746 vs 311 ng/ml) than that in control group. The greater AUC and higher C(max) in treated group could be due to inhibition of omeprazole metabolism by fluconazole.

References

Oct 1, 1977·Journal of Pharmacokinetics and Biopharmaceutics·F B EatmanS A Kaplan
Feb 1, 1992·The British Journal of Dermatology·D J BackS M Abel
Jan 6, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M MauriceP Maurel
Sep 1, 1991·Clinical Pharmacokinetics·T Andersson
Nov 14, 1997·Clinical Pharmacology and Therapeutics·Y BöttigerL Bertilsson
Mar 10, 2000·Clinical Pharmacokinetics·K VenkatakrishnanD J Greenblatt
Jun 6, 2000·Advanced Drug Delivery Reviews·D D ShenK E Thummel

❮ Previous
Next ❯

Citations

Feb 20, 2014·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Ralph-Steven Wedemeyer, Henning Blume
May 26, 2006·Antimicrobial Agents and Chemotherapy·Ville-Veikko HynninenKari Laine
Dec 14, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Brett GlotzbeckerRobert Soiffer
Jul 9, 2010·Clinical Pharmacokinetics·Ryuichi Ogawa, Hirotoshi Echizen
Nov 29, 2011·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Yohei KosugiToshiya Moriwaki
Jun 5, 2012·European Journal of Clinical Pharmacology·Antonio RuggieroRiccardo Riccardi
Oct 1, 2013·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Yohei KosugiToshiya Moriwaki
Jul 17, 2014·European Journal of Clinical Pharmacology·Ben D SnyderMatthew P Doogue
Aug 12, 2016·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Ma Ángeles Fernández de Palencia EspinosaAlberto Espuny Miró
Apr 11, 2018·Expert Opinion on Drug Metabolism & Toxicology·Aditya K GuptaNeil H Shear
May 6, 2020·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Khaled A ShibanyStuart W Paine
Jan 4, 2018·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Yannick ParmentierBernard Walther
Aug 6, 2008·European Journal of Clinical Pharmacology·Shaojun Shi, Ulrich Klotz
Nov 24, 2011·European Journal of Clinical Pharmacology·Tiina KaronenJanne T Backman
Jun 4, 2019·European Journal of Hospital Pharmacy. Science and Practice·Valeria VinciguerraCarla Rolle
Aug 21, 2003·American Journal of Clinical Dermatology·Lori ShapiroNeil Shear
Jul 19, 2020·Drug Metabolism and Personalized Therapy·Carmela Emma CoralloSharon Avery

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.