Influence of folate serum concentration on plasma homocysteine levels in HIV-positive patients exposed to protease inhibitors undergoing HAART

Annals of Nutrition & Metabolism
Maria Cristina UccelliGiampiero Carosi

Abstract

Homocysteinemia (Hcy) increase and risk factors in HIV-positive patients are not clear yet. HIV-positive patients on stable highly active antiretroviral therapy (HAART) regimens for at least 6 months were enrolled in this cross-sectional study. Among other factors, vitamin B12, folate and length of exposure to protease inhibitors (PIs) were evaluated for their possible correlation with hyper-Hcy (>13 micromol/l in females; >15 micromol/l in males) by logistic regression analysis. Ninety-eight HIV-positive patients were recruited. Twenty-eight (28.6%) had hyper-Hcy. Length of exposure to antiretroviral therapy and PIs did not result to be significantly associated with hyper-Hcy risk. Normal folate level was the only factor associated with the outcome, resulting protective from hyper-Hcy, either at univariate (OR = 0.22; CI 95% = 0.06-0.86; p = 0.029) and multivariable (OR = 0.24; CI 95% = 0.06-0.94; p = 0.04) logistic regression analysis. Folate predictive value of hyper-Hcy risk was driven by levels in the lowest quartiles of the study population (i.e. <10.9 nmol/l). No significant correlations were observed between hyper-Hcy and length of exposure to antiretroviral therapy or PIs. Folate could be a confounding factor in the as...Continue Reading

References

Jul 1, 1991·European Journal of Haematology·A F RemachaE Gimferrer
May 1, 1993·Research in Virology·P PatonR Tete
Sep 4, 1999·Annals of Internal Medicine·J W EikelboomS Yusuf
Oct 6, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J D PassalarisM J Glesby
Jun 16, 2001·AIDS·E BernasconiUNKNOWN Swiss HIV Cohort Study
Dec 12, 2001·European Journal of Clinical Investigation·M A VilasecaC Fortuny
Jan 26, 2002·Clinical Cardiology·James H SteinMichael C Fiore
Nov 14, 2002·Clinical Cardiology·Marc Cohen
Nov 20, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Pål I HolmMartin den Heijer
Jun 29, 2005·Archives of Internal Medicine·Jane DurgaPetra Verhoef

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Citations

Apr 1, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Farbod RaiszadehMarshall J Glesby
Feb 23, 2010·Enfermedades infecciosas y microbiología clínica·Sebastián HernándezEnric Pedrol
Sep 21, 2013·Nutrition·Rafael DeminiceAlceu A Jordao
Jan 2, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Marco BongiovanniTeresa Bini
Jan 16, 2007·Current Opinion in Lipidology·Robert Cramb
Mar 31, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Erika Coria-RamirezAbraham Majluf-Cruz

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