Influence of food and marker length on gastric emptying of indigestible radiopaque markers in healthy humans

Gastroenterology
H J Smith, M Feldman

Abstract

A simple, noninvasive radiographic method was used to investigate the influence of food and of marker length on gastric emptying of indigestible solids. Ten healthy human subjects who had fasted for 12 h exhibited more rapid emptying when solid radiopaque markers were ingested with water than they did when markers were ingested with a 400-kcal solid and liquid meal. Mean (+/- SE) emptying of markers that were 10 mm in length averaged 55% +/- 15%, 97% +/- 3%, and 100% 1, 2, and 4 h after ingestion of the markers with water, compared with 4% +/- 2%, 32% +/- 11%, and 64% +/- 12% emptying 1, 2, and 4 h after ingestion of markers with the meal (p less than 0.05). Ingestion of a second and third test meal significantly prolonged gastric emptying of indigestible markers (p less than 0.05). No significant difference in emptying of the 10- and 2-mm markers from the stomach was detected. These experiments indicate that gastric emptying of indigestible solids in humans is strongly influenced by food intake, but not by the particle lengths studied.

Citations

Feb 1, 1996·Scandinavian Journal of Gastroenterology·C S ChangC K Huang
Sep 26, 2003·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·I R van der VoortH Mönnikes
Feb 6, 2008·Expert Opinion on Drug Metabolism & Toxicology·Dag Nyholm, Hans Lennernäs
Jul 15, 2020·Biotechnology and Bioengineering·Zhong YuFangang Meng
Aug 1, 1994·Biopharmaceutics & Drug Disposition·H TakahashiH Shimamura
Sep 23, 1997·Scandinavian Journal of Gastroenterology·C F TungS J Wang
Jul 5, 2002·World Journal of Surgery·Toshihiro NakabayashiHiroyuki Kuwano
Mar 24, 2000·Journal of Clinical Gastroenterology·W J Snape
Mar 4, 2005·Scandinavian Journal of Gastroenterology·M LorenoA Brogna
Jan 1, 1992·European Journal of Clinical Pharmacology·I Walter-Sack
Apr 1, 1995·British Journal of Clinical Pharmacology·D A AdkinI R Wilding
Jul 21, 1998·Scandinavian Journal of Gastroenterology·C S ChangG H Chen
Jan 16, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·D CassillyH P Parkman
Oct 21, 1999·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·N V LesterC S Hartless
Apr 12, 2002·American Journal of Surgery·Toshihiro NakabayashiHiroyuki Kuwano
Jan 1, 1992·Pharmacology & Therapeutics·S W Sanders, J G Moore

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