Influence of fruit juices on drug disposition: discrepancies between in vitro and clinical studies

Expert Opinion on Drug Metabolism & Toxicology
Dora Farkas, David J Greenblatt

Abstract

Grapefruit juice is known to alter the pharmacokinetics of over 30 prescription drugs by increasing their bioavailabilities. After the discovery of this interaction almost 20 years ago, there have been many reports investigating the effects of fruit juices on drug disposition. This article reviews the literature on fruit juice-prescription drug interaction studies to determine which juices are likely to cause clinically significant interactions. We examined the results from in vitro and clinical studies regarding the interactions between prescription drugs and over ten fruit beverages. Grapefruit juice and Seville orange juice caused several clinically significant interactions with cytochrome P4503A (CYP3A). The OATP drug transporter was inhibited by grapefruit juice, orange juice, and apple juice. Other fruit juices also interacted with drug metabolizing enzymes and transporters in vitro, but more studies are needed to determine whether these interactions are clinically significant.

References

Feb 2, 1991·Lancet·D G BaileyJ M Arnold
May 1, 1995·Clinical Pharmacology and Therapeutics·M P DucharmeD J Edwards
Jan 1, 1995·Toxicology and Applied Pharmacology·M H SiessM Suschetet
May 5, 1998·Chemical Research in Toxicology·K HeP F Hollenberg
May 20, 1998·Clinical Pharmacology and Therapeutics·T KantolaP J Neuvonen
Oct 3, 1998·Clinical Pharmacology and Therapeutics·D G BaileyJ R Bend
Jan 1, 1999·Clinical Pharmacology and Therapeutics·J J LiljaP J Neuvonen
May 5, 1999·Pharmaceutical Research·A SoldnerL Z Benet
Aug 17, 1999·Biochemical and Biophysical Research Communications·Y J ChunF P Guengerich
Feb 19, 2000·Life Sciences·L Frémont
Jun 22, 2000·Archives of Biochemistry and Biophysics·W TassaneeyakulY Yamazoe
Aug 17, 2000·Clinical Pharmacology and Therapeutics·G K DresserS G Carruthers
Dec 5, 2000·Clinical Pharmacology and Therapeutics·D G BaileyJ R Bend
Mar 27, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P DebersacM H Siess
Jul 14, 2001·Clinical Pharmacology and Therapeutics·E M OffmanD G Bailey
Jul 31, 2001·Journal of Clinical Psychopharmacology·D J GreenblattR I Shader
Feb 19, 2002·The Journal of Pharmacy and Pharmacology·Leva StupansMichael Murray
Aug 17, 2002·The Journal of Pharmacology and Experimental Therapeutics·Tsutomu KotegawaDavid J Greenblatt
Oct 3, 2002·Journal of Agricultural and Food Chemistry·Xiaojun YanCatherine C Neto
Jun 18, 2003·Clinical Pharmacology and Therapeutics·David G BaileyJohn R Bend
Aug 2, 2003·Clinical Pharmacology and Therapeutics·David J GreenblattMiguel A Zinny
Sep 5, 2003·Journal of Clinical Pharmacology·Maria L VeroneseHoward E Greenberg
Dec 4, 2003·European Journal of Clinical Investigation·G K Dresser, D G Bailey
Dec 18, 2003·European Journal of Clinical Nutrition·A Dahan, H Altman
Dec 20, 2003·BMJ : British Medical Journal·Rafe SuvarnaLeigh Henderson
Mar 6, 2004·Clinical Pharmacology and Therapeutics·Jari J LiljaPertti J Neuvonen

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Citations

Jun 2, 2009·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Aminah Jatoi
Dec 31, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Ngoc NgoMary F Paine
Dec 10, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Mara S MeyerKarl T Kelsey
Dec 20, 2012·Expert Review of Molecular Diagnostics·Miao HuBrian Tomlinson
Jan 25, 2011·Expert Opinion on Drug Metabolism & Toxicology·Michael J HanleyDavid J Greenblatt
Nov 12, 2010·Expert Opinion on Drug Metabolism & Toxicology·Clemence TariraiJosias H Hamman
Jul 16, 2009·Drug Metabolism Reviews·Alan BoobisKeith Tipton
Aug 14, 2012·Pharmacology & Therapeutics·Christina S WonMary F Paine
Dec 2, 2011·Trends in Pharmacological Sciences·Dilek IusufAlfred H Schinkel
Aug 10, 2011·Advanced Drug Delivery Reviews·Ikumi Tamai
Aug 22, 2009·British Journal of Clinical Pharmacology·Kentarou UshijimaAkio Fujimura
Nov 3, 2010·British Journal of Clinical Pharmacology·David G Bailey
Jan 17, 2012·British Journal of Clinical Pharmacology·Ulrike Graefe-ModyHans-Juergen Woerle
Apr 20, 2011·British Journal of Clinical Pharmacology·Patrick ReddyKevin Browne
Aug 26, 2010·Paediatric Anaesthesia·Peter LarssonBrian J Anderson
Sep 5, 2012·British Journal of Clinical Pharmacology·Michael J HanleyDavid J Greenblatt
Jul 19, 2012·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·David J GreenblattFrederick G Gmitter
Aug 2, 2012·Drug Metabolism and Pharmacokinetics·Miao HuBrian Tomlinson
Mar 19, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Erik SjögrenPeter Langguth
Mar 31, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Christian VlachojannisSigrun Chrubasik-Hausmann
Aug 27, 2010·Statistical Methods in Medical Research·Stephen SennSteven A Julious
Jan 8, 2019·Critical Reviews in Food Science and Nutrition·Danyue ZhaoQingli Wu
Feb 11, 2015·Journal of Applied Physiology·Anne HeckstedenTim Meyer
Apr 29, 2018·Journal of Food and Drug Analysis·Meng ChenQuan Zhou
Dec 31, 2020·Foods·Zvonimir PetricDanijela Bursać Kovačević
Aug 18, 2021·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·May AlmukainziMaha Bashiri

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