Influence of GABAergic inhibition on concerted activity between the ganglion cells

Neuroreport
Wei JingPei-Ji Liang

Abstract

In this study, the spike discharges of one subtype of bullfrog retinal ganglion cells (dimming detectors) in response to repetitive full field light-OFF stimuli were recorded using multi-electrode arrays. Two different types of concerted activity (precise synchronization and correlated activity) could be distinguished. The nearby cells with overlapped receptive field areas often fired in synchrony, whereas the correlated activity was mainly observed from remote cell pairs with separated receptive fields. After the bicuculline application, the strength of the synchronized activity was increased whereas that of the correlated activity was decreased. These results suggest that the activation of GABAA-receptor-mediated inhibitory pathways differentially modulates the concerted firing of the ganglion cells.

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Citations

Sep 25, 2010·Journal of Computational Neuroscience·Wen-Zhong LiuPei-Ji Liang
Jan 7, 2014·Journal of Computational Neuroscience·Lei XiaoPei-Ji Liang
Nov 20, 2014·International Journal of Neural Systems·Lei WangYi-Hong Qiu
Jul 30, 2014·Frontiers in Neural Circuits·Lei XiaoPei-Ji Liang

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