PMID: 8591790Nov 1, 1995Paper

Influence of gas composition on convective and diffusive intrapulmonary gas transport

Experimental Lung Research
H SchulzJ Heyder

Abstract

The influence of gas composition on convective and diffusive gas transport in the lungs was assessed by studying the dispersion of combined particle and argon (Ar) boluses induced by the passage through the lungs filled with three different gas mixtures. Particles, as a "nondiffusing gas," served as a tracer for convective gas transport, while the significance of diffusive gas transport was inferred from the difference in the behavior of Ar and particles. The lungs of six anesthetized and mechanically ventilated beagle dogs were equilibrated with air or either of the test atmospheres, He-O2 or SF6-O2, where nitrogen was replaced by helium (He) or sulfur hexafluoride (SF6). Due to differences in gas density and gas viscosity Reynolds numbers varied by a factor of twelve and Ar diffusivity by a factor of four between He-O2 and SF6-O2, suggesting that both kinds of intrapulmonary gas transport, convection and diffusion, should be affected. Combined particle and Ar boluses were inhaled into various lung depths and the extent of gas transport was inferred from changes in bolus shape induced by the passage through the lungs. In air, convective bulk gas transport generally followed the symmetric first-in, last-out principle and acted ...Continue Reading

References

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Citations

Oct 24, 2003·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Holger SchulzJoachim Heyder
Mar 15, 2006·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Thomas L MillerThomas H Shaffer
Jun 15, 2004·Journal of Applied Physiology·Holger SchulzJoachim Heyder
Oct 17, 2003·Intensive Care Medicine·Enrico Calzia, Peter Radermacher
Jan 1, 2005·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·Chantal Darquenne, G Kim Prisk
Oct 7, 2020·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Sabine HäussermannGerhard Scheuch

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