Influence of gastrin on human astrocytic tumor cell proliferation

Journal of the National Cancer Institute
Isabelle CambyRobert Kiss

Abstract

Gastrin and cholecystokinin (CCK) mediate their effects through at least two types of receptors (CCK receptors A and B). While it has been hypothesized that gastrin, a stimulator of gastric acid secretion, is also a neurotransmitter and a stimulator of cell proliferation in various normal and neoplastic tissues, its effect on astrocytic brain tumors has not been actively investigated. Our goal was to determine the effects of gastrin and gastin and/or CCK antagonists on the proliferation in vitro of astrocytic tumor cells by use of both established cell lines and primary cell cultures of tumor tissue. Ten established astrocytic tumor cell lines, SW1088, SW1783, Hs683, H4, U87, U118, U138, U373, T98G, and A172, were studied. The effects of added gastrin (at 0.01, 0.1, and microM) and the gastrin/CCK antagonists L-365,260, CI-988, L-364,718, and JMV 234 (each at 0.01, 0.1, and 1 microM) on the cellular proliferation rates of the 10 cell lines were indirectly measured by use of the colorimetric tetrazolium assay. The influence of gastrin (at 0.01 microM) on the cellular proliferation of primary cultures from nine freshly explanted astrocytic tumors was assessed by means of tritiated thymidine uptake and autoradiography. At specific...Continue Reading

Citations

May 26, 2005·Journal of Neuroimmunology·Alexandra Berger, Christopher J Paige
Jun 1, 2005·Phytochemistry·Anh-Tho NguyenPierre Duez
Jul 12, 2002·Bioorganic & Medicinal Chemistry·Christine BrahicEvelyne Delfourne
Nov 25, 2000·Journal of Pharmacological and Toxicological Methods·S FarinelleR Kiss
Oct 19, 2007·Journal of Asian Natural Products Research·Chang-Lun ShaoShi-Ning Zhou
Oct 7, 2011·Natural Product Research·Zhongjing HuangYongcheng Lin
Apr 16, 2013·Natural Product Research·Jianxiang YangYongcheng Lin
Jan 5, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D EgriseA Schoutens
Nov 12, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Alexander SturzuStefan Heckl
Oct 26, 2005·Neoplasia : an International Journal for Oncology Research·Véronique MathieuRobert Kiss
Jun 23, 2006·Neoplasia : an International Journal for Oncology Research·Tatjana MijatovicRobert Kiss
Nov 7, 2006·Neuropathology and Applied Neurobiology·S ServotteC Decaestecker
Sep 9, 2011·International Journal of Cancer. Journal International Du Cancer·Anke WahaAndreas Waha
Jun 15, 2004·Experimental Cell Research·A GaigneauxE Goormaghtigh
Aug 11, 2006·Phytochemistry·Anh-Tho NguyenPierre Duez
Jul 12, 2005·Toxicology and Applied Pharmacology·Caroline HayotChristine Decaestecker
Nov 24, 2004·Biochemical and Biophysical Research Communications·Charles DebrayRoland Pochet
Oct 26, 2005·Fitoterapia·Hai-Feng TangYue-Ping Zhao
Jun 18, 2002·The Journal of Pharmacology and Experimental Therapeutics·Julie PannequinJean Martinez
Sep 10, 2002·Laboratory Investigation; a Journal of Technical Methods and Pathology·Florence LefrancRobert Kiss
Apr 30, 2017·Frontiers in Endocrinology·Jens F Rehfeld
Feb 19, 2002·Laboratory Investigation; a Journal of Technical Methods and Pathology·Carine DelbrouckRobert Kiss
Nov 25, 2000·Laboratory Investigation; a Journal of Technical Methods and Pathology·S SteinfeldR Kiss
May 8, 2003·Acta Neuropathologica·Alexandra BergerBarbara Kofler
Dec 30, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Florence LefrancRobert Kiss

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