PMID: 15371919Sep 17, 2004Paper

Influence of gastritis on cyclooxygenase-2 expression before and after eradication of Helicobacter pylori infection

European Journal of Gastroenterology & Hepatology
Casmir WamburaMasato Kasuga

Abstract

Helicobacter pylori infection causes chronic gastritis and induces cyclooxygenase (COX)-2 expression. The relationship between gastritis and COX-2 expression is not well understood, especially long after the organism has been eradicated. We designed a study to elucidate this relationship. Four endoscopic gastric biopsies from each of 118 H. pylori-infected subjects were assessed for COX-2 expression immunohistochemically, gastritis, by an updated Sydney System. In the 107 successfully eradicated subjects, the assessment was repeated once yearly, for 3 years. After successful eradication, COX-2 expression was reduced significantly regardless of site. Atrophy improved significantly and intestinal metaplasia improved but not in the antrum greater curvature. After 1 year COX-2 expression was not significantly different in the epithelia with and without intestinal metaplasia. Correlation between COX-2 expression and neutrophil score in the antrum (r = 0.214, P = 0.042) and inflammation in the corpus (r = 0.234, P = 0.025) disappeared after eradication. COX-2 expression correlated well with atrophy and metaplasia before and after eradication. No significant reduction in COX-2 or improvement in gastritis was found in subjects with era...Continue Reading

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Citations

Sep 26, 2012·BMC Gastroenterology·Harald E VonkemanBac Dijkmans
Mar 1, 2012·World Journal of Gastroenterology : WJG·Paulo R C AlmeidaRonaldo A Ribeiro
Jun 11, 2014·World Journal of Gastroenterology : WJG·Yan-Jun KongMu-Xin Wei
Apr 9, 2015·Journal of Cancer Prevention·Yo Han Park, Nayoung Kim
Jul 9, 2005·European Journal of Gastroenterology & Hepatology·Kazimierz RembiaszJerzy Stachura
Apr 6, 2006·World Journal of Gastroenterology : WJG·Shingo TsujiNorio Hayashi
Oct 3, 2018·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Kichul Yoon, Nayoung Kim

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