Influence of gender and age on course of infection and cytokine responses in mice with disseminated Cryptococcus neoformans infection

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
O LortholaryF Dromer

Abstract

To study the influence of gender and age on the course of infection and the cytokine response in a murine model of disseminated cryptococcosis. The course of the infection (survival and fungal load in blood and tissues) as well as pro-inflammatory and anti-inflammatory cytokine responses in plasma and organs were compared according to gender and age in outbred mice previously infected with Cryptococcus neoformans NIH52D. Although survival and fungal load were similar in male and female mice, the expression of all cytokines in plasma and of tumour necrosis factor-alpha and interferon-gamma in spleen was significantly increased in female mice compared to male mice in two independent experiments. Young male mice had a significantly shortened survival, were significantly more infected and had predominant tumour necrosis factor-alpha and interferon-gamma responses in comparison with older male mice. Host factors should be taken into account when studying the immune response to experimental C. neoformans infection. Our data support epidemiological and clinical data showing differences in susceptibility to cryptococcosis according to gender and age.

References

Nov 1, 1991·Reviews of Infectious Diseases·B Styrt, B Sugarman
Jan 1, 1989·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·D A Stevens
Feb 1, 1974·Annals of Internal Medicine·R D Diamond, J E Bennett
Sep 1, 1995·Cellular Immunology·J W AlbrightJ F Albright
Jan 1, 1993·Advances in Microbial Physiology·G W Gooday, D J Adams
Oct 1, 1995·Clinical Microbiology Reviews·T G Mitchell, J R Perfect
Jan 1, 1996·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·N ChristeffE A Nunez
Jul 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·F DromerA Laporte
Oct 27, 1997·Clinical and Experimental Immunology·F BarratC Pilet
Nov 5, 1997·Biochemical and Biophysical Research Communications·R W KellyS C Riley
Jul 28, 1999·Medical Mycology·O LortholaryF Dromer
Oct 1, 1998·Age·E D Bernstein, D M Murasko

❮ Previous
Next ❯

Citations

Mar 29, 2011·Archivum Immunologiae Et Therapiae Experimentalis·Erin E McClelland, Jennifer M Smith
Aug 24, 2005·Médecine sciences : M/S·Caroline CharlierFrancoise Dromer
Nov 21, 2007·Medical Mycology·Javier CapillaDavid A Stevens
May 4, 2005·Surgical Infections·Michael G HughesRobert G Sawyer
Feb 8, 2007·PLoS Medicine·Françoise DromerUNKNOWN French Cryptococcosis Study Group
Nov 8, 2014·Journal of Evolutionary Biology·S V Cousineau, S Alizon
May 14, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·C AyeR Norton
Aug 2, 2016·The Journal of Investigative Dermatology·Jay-Hyun JoHeidi H Kong
May 16, 2006·FEMS Yeast Research·Kausik Datta, Liise-anne Pirofski
May 16, 2006·FEMS Yeast Research·Kaleb J MarrChristopher H Mody
Apr 20, 2018·Journal of Fungi·Tiffany E GuessErin E McClelland
Apr 30, 2008·Mycopathologia·Ana Lusia LealMarilene H Vainstein
Oct 31, 2021·Mycopathologia·Amanda Ribeiro Dos SantosJames Venturini

❮ Previous
Next ❯

Related Concepts

Related Feeds

Epidemiology of Aging

This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.