Abstract
Gender plays a crucial role in the prevalence, clinical presentation, management and outcomes of various cardiovascular diseases. The aim of this study was to evaluate the impact of gender on clinical manifestations and outcomes in the Chinese patients with hypertrophic cardiomyopathy (HCM). We evaluated 576 Chinese patients (316 males) who were diagnosed with HCM at West China Hospital from 2008 to 2016 and followed over 3.2 ± 2.3 years. Compared to male patients, female patients were older (57.2 ± 16.7 years vs. 53.0 ± 15.7 years, P = 0.002) and more symptomatic [New York Heart Association class III-IV symptoms 46.9% vs. 30.7%, P < 0.001] at the time of diagnosis, and had higher left ventricular outflow tract gradient at rest [33 (12-58) mmHg vs. 24 (8-42) mmHg, P = 0.007]. During the follow-up period, survival analysis showed no significant differences in the incidences of all-cause mortality (P = 0.657) and cardiovascular mortality (P = 0.214) but the rate of rehospitalization due to heart failure was higher in females than in males (P = 0.015). Multivariable Cox analysis showed that left ventricular ejection fraction (hazard ratio [HR], 0.96 [95% confidence interval [CI], 0.94-0.99]; P = 0.003) and New York Heart Associati...Continue Reading
References
Jan 1, 1992·Journal of the American College of Cardiology·J A PanzaB J Maron
Feb 24, 1999·JAMA : the Journal of the American Medical Association·B J MaronD M Aeppli
Jun 22, 2000·Archives of Family Medicine·L MoscaM N Hill
Nov 17, 2001·Heart·E D Wigle
Feb 19, 2002·Journal of the American College of Cardiology·Maria J ErikssonHarry Rakowski
Mar 12, 2002·JAMA : the Journal of the American Medical Association·Barry J Maron
Jan 22, 2003·Journal of the American College of Cardiology·Frederick A MasoudiHarlan M Krumholz
Jan 24, 2003·The New England Journal of Medicine·Martin S MaronBarry J Maron
Sep 4, 2003·Circulation·Melvin D CheitlinUNKNOWN American Society of Echocardiography
Nov 11, 2003·Journal of the American College of Cardiology·Barry J MaronUNKNOWN Committee for Practice Guidelines. European Society of Cardiology
Jan 7, 2004·The American Journal of Medicine·Yubao ZouRutai Hui
Jan 7, 2004·The American Journal of Medicine·Hee-Hwa HoHung-Fat Tse
Feb 6, 2004·Circulation·Lori MoscaUNKNOWN American Heart Association
Aug 2, 2005·Journal of the American College of Cardiology·Iacopo OlivottoBarry J Maron
Jun 15, 2007·Circulation·Eileen O'MearaUNKNOWN CHARM Investigators
May 9, 2008·Heart·S DeyUNKNOWN Global Registry of Acute Coronary Events investigators
Aug 12, 2008·European Journal of Heart Failure·Jeanette Schulz-MengerRainer Dietz
Mar 31, 2010·Journal of cardiology·Takayoshi HirotaYoshinori L Doi
May 4, 2010·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Patrizio LancellottiUNKNOWN European Association of Echocardiography
Aug 20, 2010·Journal of cardiology·Toru KuboYoshinori L Doi
Nov 19, 2011·The Journal of Thoracic and Cardiovascular Surgery·Bernard J GershClyde W Yancy
Jan 24, 2012·Circulation. Cardiovascular Genetics·Stephen P PageWilliam J McKenna
Sep 26, 2013·Circulation. Cardiovascular Interventions·Zhen-Gang ZhaoDe-Jia Huang
Oct 16, 2013·European Heart Journal·Constantinos O'MahonyUNKNOWN Hypertrophic Cardiomyopathy Outcomes Investigators
Aug 16, 2014·Journal of cardiology·Yasunobu TerauchiHiroaki Kitaoka
Aug 16, 2016·Cardiovascular Ultrasound·Vito Maurizio ParatoUNKNOWN Italian Chapter of ISCU
Oct 12, 2017·European Heart Journal·Jeffrey B GeskeSteve R Ommen
May 2, 2018·Circulation·Sophie WellsBarry J Maron
Feb 28, 2019·JAMA Cardiology·Zahara MeghjiHartzell V Schaff