Influence of Gender on Clinical Characteristics and Outcomes in Chinese Patients With Hypertrophic Cardiomyopathy

The American Journal of the Medical Sciences
Fang-Yang HuangShi-Jian Chen

Abstract

Gender plays a crucial role in the prevalence, clinical presentation, management and outcomes of various cardiovascular diseases. The aim of this study was to evaluate the impact of gender on clinical manifestations and outcomes in the Chinese patients with hypertrophic cardiomyopathy (HCM). We evaluated 576 Chinese patients (316 males) who were diagnosed with HCM at West China Hospital from 2008 to 2016 and followed over 3.2 ± 2.3 years. Compared to male patients, female patients were older (57.2 ± 16.7 years vs. 53.0 ± 15.7 years, P = 0.002) and more symptomatic [New York Heart Association class III-IV symptoms 46.9% vs. 30.7%, P < 0.001] at the time of diagnosis, and had higher left ventricular outflow tract gradient at rest [33 (12-58) mmHg vs. 24 (8-42) mmHg, P = 0.007]. During the follow-up period, survival analysis showed no significant differences in the incidences of all-cause mortality (P = 0.657) and cardiovascular mortality (P = 0.214) but the rate of rehospitalization due to heart failure was higher in females than in males (P = 0.015). Multivariable Cox analysis showed that left ventricular ejection fraction (hazard ratio [HR], 0.96 [95% confidence interval [CI], 0.94-0.99]; P = 0.003) and New York Heart Associati...Continue Reading

References

Feb 24, 1999·JAMA : the Journal of the American Medical Association·B J MaronD M Aeppli
Feb 19, 2002·Journal of the American College of Cardiology·Maria J ErikssonHarry Rakowski
Mar 12, 2002·JAMA : the Journal of the American Medical Association·Barry J Maron
Jan 22, 2003·Journal of the American College of Cardiology·Frederick A MasoudiHarlan M Krumholz
Jan 24, 2003·The New England Journal of Medicine·Martin S MaronBarry J Maron
Jan 7, 2004·The American Journal of Medicine·Hee-Hwa HoHung-Fat Tse
Feb 6, 2004·Circulation·Lori MoscaUNKNOWN American Heart Association
Aug 2, 2005·Journal of the American College of Cardiology·Iacopo OlivottoBarry J Maron
Mar 31, 2010·Journal of cardiology·Takayoshi HirotaYoshinori L Doi
May 4, 2010·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Patrizio LancellottiUNKNOWN European Association of Echocardiography
Sep 26, 2013·Circulation. Cardiovascular Interventions·Zhen-Gang ZhaoDe-Jia Huang
Oct 16, 2013·European Heart Journal·Constantinos O'MahonyUNKNOWN Hypertrophic Cardiomyopathy Outcomes Investigators
Aug 16, 2016·Cardiovascular Ultrasound·Vito Maurizio ParatoUNKNOWN Italian Chapter of ISCU
Oct 12, 2017·European Heart Journal·Jeffrey B GeskeSteve R Ommen

❮ Previous
Next ❯

Citations

Jul 27, 2021·Heart & Lung : the Journal of Critical Care·Kristen A Sethares, Elizabeth Chin
Aug 1, 2020·The American Journal of the Medical Sciences·Carlo Fumagalli, Iacopo Olivotto

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.