Influence of gender on the course of neuromuscular block following a single bolus dose of cisatracurium or rocuronium

European Journal of Anaesthesiology
Milan AdamusO Marek

Abstract

There is increasing evidence of gender differences in the pharmacokinetics and pharmacodynamics of aminosteroid neuromuscular blocking agents. Compared to males, females are more susceptible, requiring approximately 30% less rocuronium to achieve the same degree of neuromuscular block. However, little information is available whether this difference is applicable to modern benzylisoquinolines (cisatracurium). In all, 848 patients (423 males, 425 females) undergoing general surgery under total intravenous anaesthesia with muscle relaxation, tracheal intubation and mechanical ventilation were studied. Patients were randomized to receive a single bolus dose of cisatracurium (0.1 mg kg-1, 221 males and 199 females) or rocuronium (0.6 mg kg-1, 202 males and 226 females). The onset time for 95% depression of T1, clinical duration until 25% recovery and recovery index (T1 from 25% to 75%) were determined with an NMT electromyographic module of the Datex-Ohmeda S/5 Anaesthesia Monitor. The data for male and female groups were compared with appropriate statistical tests (unpaired t-test, Mann-Whitney rank sum test and Fisher's exact test). In both groups (cisatracurium and rocuronium), males were significantly taller (P < 0.001) and hea...Continue Reading

Associated Clinical Trials

Jul 13, 2015·Wooyoung Park, Wooyoung Park

References

Sep 1, 1992·Anaesthesia·I T HoughtonT E Oh
Nov 1, 1992·British Journal of Anaesthesia·C J ParkerS L Snowdon
Jul 1, 1985·Canadian Anaesthetists' Society Journal·S R MallampatiP L Liu
Feb 1, 1994·British Journal of Anaesthesia·P SempleA Rodbert
Dec 1, 1995·Anesthesiology·E GeptsJ J Heykants
Jan 1, 1996·Acta Anaesthesiologica Scandinavica·J Viby-MogensenD Ostergaard
Oct 15, 1998·British Journal of Anaesthesia·F S XueL K Luo
May 4, 2000·British Journal of Anaesthesia·J Viby-Mogensen
May 4, 2000·British Journal of Anaesthesia·C BaillardM Cupa
Nov 7, 2000·Acta Anaesthesiologica Scandinavica·J Viby-MogensenP M Wright
May 10, 2002·European Journal of Anaesthesiology·G CammuE Mortier
Mar 22, 2003·Acta Anaesthesiologica Scandinavica·H PleymO Dale
Jul 24, 2004·Acta Biologica Hungarica·A Ayali, Yael Zilberstein
Jun 17, 2005·Anaesthesia and Intensive Care·W AlkhazrajyW J Russell
Jun 30, 2005·Der Anaesthesist·T MenckeH Rensing
Jul 26, 2005·Annales Françaises D'anesthèsie Et De Rèanimation·M Beaussier, M A Boughaba
Apr 12, 2007·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Milan AdamusEva Janaskova

❮ Previous
Next ❯

Citations

Apr 24, 2009·Clinical Pharmacokinetics·Offie P Soldin, Donald R Mattison
Dec 11, 2013·Translational Stroke Research·Lana J MawhinneyMichael C Lewis
Jan 21, 2012·Acta Anaesthesiologica Scandinavica·C CzarnetzkiM R Tramèr
Oct 6, 2016·Korean journal of anesthesiology·Jeong Ho KimSeung Cheol Lee
Aug 20, 2009·Anesthesia and Analgesia·Christian S MeyhoffLars S Rasmussen
Sep 24, 2013·Anesthesia and Analgesia·François Donati
Sep 9, 2016·Anaesthesia and Intensive Care·C N Brett, S J Roberts
Aug 24, 2017·BMC Anesthesiology·Martin ZorembaThomas Kratz
Aug 7, 2021·Clinics in Chest Medicine·Claire C Eng, Mojdeh S Heavner
Feb 1, 2019·Journal of Clinical Anesthesia·Brian D HeslerLeif Saager

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.