Influence of Genetic Polymorphism Towards Pulmonary Tuberculosis Susceptibility

Frontiers in Medicine
Murugesan HarishankarRamalingam Bethunaickan

Abstract

Tuberculosis (TB) is still remains the major threat for human health worldwide. Several case-control, candidate-gene, family studies and genome-wide association studies (GWAS) suggested the association of host genetic factors to TB susceptibility or resistance in various ethnic populations. Moreover, these factors modulate the host immune responses to tuberculosis. Studies have reported genetic markers to predict TB development in human leukocyte antigen (HLA) and non-HLA genes like killer immunoglobulin-like receptor (KIR), toll-like receptors (TLRs), cytokine/chemokines and their receptors, vitamin D receptor (VDR) and SLC11A1 etc. Highly polymorphic HLA loci may influence antigen presentation specificities by modifying peptide binding motifs. The recent meta-analysis studies revealed the association of several HLA alleles in particular class II HLA-DRB1 with TB susceptibility and valuable marker for disease development especially in Asian populations. Case-control studies have found the association of HLA-DR2 in some populations, but not in other populations, this could be due to an ethnic specific association of gene variants. Recently, GWAS conducted in case-control and family based studies in Russia, Chinese Han, Morocco,...Continue Reading

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Citations

Jul 3, 2019·The American Journal of Tropical Medicine and Hygiene·Ji-Soo KwonSung-Han Kim
Sep 12, 2019·Frontiers in Pediatrics·Maurizio de MartinoElena Chiappini
Jan 15, 2021·Microorganisms·Ana Santos-PereiraNuno S Osório
Apr 14, 2021·The Indian Journal of Tuberculosis·Deo Kabuye, Angelamellisy Ndibalema
Apr 26, 2021·HLA : Immune Response Genetics·David J LangtonCarlos Echevarria

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Methods Mentioned

BETA
genotyping
PCR
exome sequencing
acetylation

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