PMID: 11339927May 8, 2001Paper

Influence of gestational age and maternal height on fetal femur length calculations

Obstetrics and Gynecology
B T PierceB C Calhoun

Abstract

To determine whether current methods of detecting Down syndrome based on fetal femur length calculations are influenced by gestational age or maternal height. Four formulas were used to calculate expected femur length (FL) based on the fetal biparietal diameter (BPD) between 15 0/7 weeks' gestation and 19 6/7 weeks' gestation. For each gestational age, the BPD:FL ratio for women shorter than one standard deviation (SD) below the mean height was compared with the ratio for women taller than one SD above the mean height. A measured:expected FL ratio of 0.91 or less and a BPD:FL ratio greater than 1.5 SD above the mean was considered abnormal. The four formulas used to calculate measured:expected FL ratios were significantly more likely to be abnormal at 15--16 weeks' gestation, compared with 18-19 weeks' gestation (P <.05). Maternal height correlated with femur lengths at 18 and 19 weeks' gestation (P <.05) but not at earlier gestational ages. At 18 and 19 weeks' gestation, women shorter than one SD below the mean were twice as likely to have an abnormal BPD:FL ratio compared with women taller than one SD above the mean (relative risk 2.38; 95% confidence interval 1.21, 4.69). Early gestational age increases a woman's risk of hav...Continue Reading

References

Feb 11, 1991·Obstetrics and Gynecology·B R BenacerrafF D Frigoletto
Jun 1, 1995·British Journal of Obstetrics and Gynaecology·W SepulvedaN M Fisk
Feb 1, 1993·American Journal of Obstetrics and Gynecology·D A NybergM A Williams
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Aug 11, 1998·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·D A NybergM A Williams
Jan 1, 1993·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·K NicolaidesR Snijders

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Citations

Nov 12, 2013·Journal de gynécologie, obstétrique et biologie de la reproduction·A Ego
Feb 7, 2013·BMC Pregnancy and Childbirth·Kirsti MyklestadPål Richard Romundstad
Jul 20, 2005·Acta Obstetricia Et Gynecologica Scandinavica·Synnøve Lian JohnsenTorvid Kiserud
Jan 25, 2005·BJOG : an International Journal of Obstetrics and Gynaecology·Isabelle MorinMichael S Kramer
Apr 28, 2009·American Journal of Obstetrics and Gynecology·Keith K Ogasawara
Jun 15, 2016·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·H Cuckle
Apr 3, 2004·Seminars in Perinatology·David A NybergYves Ville

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