PMID: 9094752Jan 15, 1997Paper

Influence of glucose concentration on the inhibitory effect of amylin on insulin secretion. Study in the perfused rat pancreas

Regulatory Peptides
R A SilvestreJ Marco


The effect of amylin on insulin secretion is a matter of controversy. Short-term experiments have shown that amylin, at 75 pmol/l, inhibits the insulin release elicited by a modest increase in the perfusate glucose concentration (from 5.5 mmol/l to 9 mmol/l). The present work was undertaken to further investigate the effect of amylin on glucose-induced insulin release at different glucose concentrations. The study was performed in the isolated perfused rat pancreas. Amylin, at 75 pmol/l, markedly blocked the insulin response when the perfusate glucose concentration was increased from 3.2 mmol/l to 7 mmol/l (by 90%; P < 0.01) or from 5.5 mmol/l to 9 mmol/l (by 80%; P < 0.01). At the same amylin concentration, no significant inhibition of insulin output was observed when the perfusate glucose level was augmented from 5.5 mmol/l to 16.6 mmol/l, from 7 mmol/l to 11 mmol/l or from 9 mmol/l to 13 mmol/l. At a higher concentration (750 pmol/l), amylin also failed to inhibit the insulin response induced by increasing glucose levels from 5.5 mmol/l to 16.6 mmol/l or from 9 to 13 mmol/l. These findings indicate that, in the rat pancreas, amylin only inhibits insulin release when evoked by elevations of glucose levels comparable to those ...Continue Reading


Mar 30, 1990·Biochemical and Biophysical Research Communications·H C FehmannR Arnold
Jun 28, 1991·Biochemical and Biophysical Research Communications·C L BroderickG Gold
Aug 16, 1990·Biochemical and Biophysical Research Communications·T D O'BrienK H Johnson
Feb 13, 1986·Biochemical and Biophysical Research Communications·R A SilvestreJ Marco
May 1, 1987·Diabetologia·D Pipeleers
Oct 1, 1965·The Journal of Clinical Endocrinology and Metabolism·V HerbertS J Bleicher
Apr 1, 1983·Diabetologia·D R MatthewsR C Turner
Jul 1, 1995·Canadian Journal of Physiology and Pharmacology·K BeaumontA A Young
Jul 1, 1960·The Journal of Clinical Investigation·R S YALOW, S A BERSON

❮ Previous
Next ❯


Apr 27, 2002·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A VellaP D Klein
Jan 10, 2018·Anatomia, histologia, embryologia·H Suzuki, T Yamamoto
Jul 12, 2011·Physiological Reviews·Per WestermarkGunilla T Westermark
Feb 15, 2001·American Journal of Physiology. Endocrinology and Metabolism·R A SilvestreJ Marco
Jun 22, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·M SamsomR A Rizza
Oct 13, 2021·Journal of Cellular Physiology·Carine MarmentiniMirian A Kurauti

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.