Influence of glutamine on pancreatic blood flow and apoptosis of pancreatic acinar in rats with severe acute pancreatitis

Chinese Journal of Digestive Diseases
Xue Feng XuZhao Han Wu

Abstract

To investigate the role of glutamine on splanchnic blood flow, apoptosis of pancreatic acinar and the underlying mechanism in rats with severe acute pancreatitis. Forty-eight rats were randomized into two groups: the glutamine group (n = 24) and the severe acute pancreatitis group (n = 24). Jejunotomy was performed in all rats: the glutamine group also received glutamine, and the severe acute pancreatitis group received normal saline. Each group was then subdivided into three subgroups of eight rats each, with the rats be killed at 12, 24 and 36 h after the operation, respectively. A control group underwent sham operation (n = 8). The regional pancreatic microvascular blood flow was measured by Doppler ultrasound. The blood flow of the portal vein, splenic artery and superior mesenteric artery were also recorded. Apoptosis of pancreatic acinar cells was evaluated by TUNEL method. The regional pancreatic microvascular blood flow (KHz) decreased significantly in the severe acute pancreatitis group (P < 0.01), and continued to decrease after 24 h (vs. 12 h, P < 0.01). The blood flow of the portal vein, splenic artery and superior mesenteric artery also decreased in the severe acute pancreatitis group. The glutamine group showed in...Continue Reading

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Citations

Nov 26, 2008·World Journal of Gastroenterology : WJG·Xi-Ping ZhangWen-Qin Yuan
Oct 1, 2013·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Ilse RoomanSimone M R Camargo
Oct 31, 2009·Journal of Gastroenterology and Hepatology·Zhang XipingBai Jinjin
Aug 26, 2014·The Journal of Surgical Research·Etem AlhanCengiz Erçin
Dec 3, 2009·Inflammation·Zhang XipingFang Lini
Jun 21, 2008·World Journal of Gastroenterology : WJG·Xi-Ping ZhangTong-Fa Ju
Jun 21, 2008·World Journal of Gastroenterology : WJG·Min-Jie ZhangLi-Feng Huang
Jun 15, 2017·World Journal of Gastroenterology : WJG·Jun LiZong-Fang Li

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

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