Influence of glutardialdehyde on dentin demineralization in vitro and in vivo

Scandinavian Journal of Dental Research
J ArendsG Rölla

Abstract

In this paper the results are presented on the action of glutardialdehyde (GDA) on the in vitro demineralization of human dentin and on the in vivo demineralization of dentin using the Ogaard orthodontic banding system. The results show that a 2 min application of a 2% GDA solution at pH = 3.6 reduces dentin demineralization in vitro and in vivo substantially. Microradiography shows a percentage reduction of lesion depth and mineral loss in vitro of 20 and 36%, respectively. After 2 wk in vivo demineralization the same percentage reductions are 60 and 44%, respectively. The mechanism of action of GDA on dentin is not certain yet. Presumably the in vitro action is due to surface cross-linking of the dentin matrix causing reduced Ca and phosphate transport out of the dentin. In vivo an additional effect may be a rather short term influence of GDA on plaque or on plaque accumulation. The results of this paper indicate that glutardialdehyde is an interesting agent to consider in the reduction of root caries.

References

Oct 1, 1985·Physics in Medicine and Biology·E de Josselin de Jong, J J ten Bosch
Sep 1, 1982·Oral Surgery, Oral Medicine, and Oral Pathology·J C WemesW Vaalburg
Feb 1, 1963·Journal of Ultrastructure Research·B ANGMARJ E GLAS

❮ Previous
Next ❯

Citations

Nov 10, 2010·Journal of Oral Rehabilitation·P H dos SantosA K B Bedran-Russo
Dec 8, 2010·Periodontology 2000·Jonas A RodriguesKlaus W Neuhaus
Jun 4, 2015·European Journal of Dentistry·Berdan AydınTugba Turk
May 3, 2011·Journal of Biomechanics·Paulo Henrique Dos SantosAna Karina Bedran-Russo
Nov 1, 1995·Advances in Dental Research·M Colbert

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.