PMID: 7538305Jan 1, 1994Paper

Influence of gonadal hormones on sexual differences in sensitivity to methamphetamine-induced neurotoxicity

Journal of Neural Transmission. Parkinson's Disease and Dementia Section
Y L Yu, G C Wagner

Abstract

The administration of high doses of methamphetamine to mice causes long-lasting depletions of striatal dopamine to a greater extent in males than in females. Likewise, the incidence of Parkinson's disease is higher in males than in females. The present study investigated the roles of estrogen and testosterone in mediating the dopamine depletion induced by methamphetamine. Male and female mice received four cumulative SC doses of methamphetamine (10 mg/kg) at two hour intervals and were sacrificed two weeks later for HPLC analysis of striatal monoamines. Intact male mice were found to have a 76% dopamine depletion, which was significantly greater than the 37% depletion exhibited by the intact female mice. Neither removal of the ovaries nor removal of the testes one month prior to the methamphetamine treatment significantly changed the magnitude of the methamphetamine-induced dopamine depletion. Thus, the reduced sensitivity of female mice to methamphetamine may be independent of physiological gonadal hormones.

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Citations

Oct 28, 1996·Brain Research·J Kume-KickM E Rice
Jun 18, 2002·European Journal of Pharmacology·Charles W SchindlerEric B Thorndike
Apr 26, 2003·Neurobiology of Aging·Michael CollaIsabella Heuser
Dec 28, 2000·Progress in Neuro-psychopharmacology & Biological Psychiatry·L YuG C Wagner
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Dec 19, 2006·Neurotoxicology and Teratology·Ellen D Witt
Nov 16, 2004·Annals of the New York Academy of Sciences·Dean E Dluzen, Janet L McDermott
Mar 13, 2014·Frontiers in Neuroendocrinology·Glenda E GilliesZahi Qamhawi
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Jul 15, 2004·Pharmacology, Biochemistry, and Behavior·Glenda E GilliesSimon McArthur
Apr 18, 2006·Biological Psychiatry·Cynthia A MunroGary S Wand
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Oct 15, 2008·Neuroscience Letters·Chandani Lewis, Dean E Dluzen
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Feb 22, 2021·Ageing Research Reviews·Nikolai JaschkeTilman D Rachner

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