Influence of gradually increased slow balloon inflation on restenosis after coronary angioplasty

American Heart Journal
S MiketicU Tebbe

Abstract

Balloon inflation during coronary angioplasty results in shear stress-induced vessel wall injury with development of restenosis. This randomized trial compared the impact of two different balloon inflation strategies (slow versus fast) on restenosis after coronary angioplasty. Two hundred seven patients were randomized to undergo either fast or gradually increased slow inflation after successful placement of the balloon catheter inside the target lesion. One hundred six underwent fast, and 101 underwent gradually increased slow balloon inflation. Coronary angiograms were quantitatively analyzed before angioplasty, after angioplasty, and at follow-up 5.9+/-1.6 months after the initial procedure. Both groups had an identical primary success rate (98.1% vs 98%; p = 0.96) and a similar minimal luminal diameter before (0.49+/-0.26 mm vs 0.48+/-0.22 mm; p = 0.8) and after (2.22+/-0.97 mm vs 2.26+/-0.66 mm; p = 0.7) angioplasty. Slow balloon inflation did not reduce late luminal loss (0.58+/-0.77 mm vs 0.74+/-0.87 mm; p = 0.2), net gain (1.33+/-0.84 mm vs 1.19+/-0.81 mm; p = 0.3), or minimal luminal diameter at follow-up (1.80+/-0.97 mm vs 1.72+/-1.0 mm; p = 0.6) significantly. Restenosis, defined as >50% diameter stenosis at follow-u...Continue Reading

References

Feb 1, 1992·Journal of the American College of Cardiology·S G Ellis, D W Muller
Sep 1, 1991·Circulation·J J PopmaE J Topol
Mar 1, 1995·Catheterization and Cardiovascular Diagnosis·J C BlankenshipC M Frey
May 1, 1994·Journal of the American College of Cardiology·J A BittlD S Baim

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Citations

Jul 11, 2012·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Kostantinos MarmagkiolisLuc Bilodeau

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