Influence of growth and transcriptional factors, and signaling molecules on early human pituitary development.

Journal of Molecular Histology
Mirna BazinaM Saraga-Babić

Abstract

Development and differentiation of the human pituitary gland was investigated in 6 human conceptuses 6-9 postovulatory weeks old, using immunohistochemical technique to investigate appearance of different developmental factors, and immunofluorescent double staining technique with Ki-67 to investigate proliferation. In the developing human pituitary gland, different developmental factors appeared in temporally and spatially restricted patterns, thus contributing to formation of different parts of the gland: adenohypophysis, neurohypophysis and associated mesenchyme. Some growth factors were not primarily involved in cell proliferation (TGF-ss, BMP-2/4 and GATA), but in differentiation of pituitary cells: TGF-ss, BMP-2/4 and GATA probably contributed to differentiation of cells in the mesenchyme at earlier stages, while their influence on differentiation of specific cell types in the adenohypophysis increased with development. At later developmental stages, those factors also influenced the differentiation of cells in the neurohypophysis. FGF-8 and FGF-10 probably participated both in the growth and differentiation of pituitary cells: while FGF-8 could act during early developmental stages, FGF-10 participated in the same process...Continue Reading

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Citations

Jan 26, 2011·Expert Review of Endocrinology & Metabolism·Paraskevi XekoukiConstantine A Stratakis
Feb 1, 2014·Journal of Neuro-oncology·Elena D Aflorei, Márta Korbonits
Aug 2, 2021·Biology of Reproduction·Robert T RydzeStephanie A Pangas
Dec 24, 2010·Current Opinion in Endocrinology, Diabetes, and Obesity

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