Influence of growth hormone replacement on neurological and psychomotor development. Case report

Einstein
Felipe MottaLindiane Gomes Crisostomo

Abstract

The height response to the use of growth hormone in short height cases has already been confirmed in the literature. The influence of the insulin-like growth factor 1 (GH-IGF1) axis components on development, function, regeneration, neuroprotection, cognition, and motor functions has been evaluated in experimental studies and in adults with central nervous system lesions. However, there is still little research on the clinical impact of hormone replacement on neurological and psychomotor development. This report presents the case of a patient with excellent weight-height recovery and, even more surprisingly, neurological and psychomotor development in response to use of growth hormone. The result strengthens the correlation between experimental and clinical findings related to cerebral plasticity response to growth hormone in children. A preterm male patient with multiple health problems during the neonatal and young infancy period, who for six years presented with a relevant deficit in growth, bone maturation, and neurological and psychomotor development. At six years of age, he had low stature (z-score -6.89), low growth rate, and low weight (z-score -7.91). He was incapable of sustaining his axial weight, had not developed f...Continue Reading

References

Apr 20, 2004·The European Journal of Neuroscience·Mark I RansomeAnn M Turnley
Oct 22, 2011·Neurobiology of Aging·Doris P MolinaMichelle M Adams
Sep 17, 2013·Journal of Clinical Epidemiology·Joel J GagnierUNKNOWN CARE Group
Jan 24, 2014·Endocrine Reviews·Kyriaki S AlatzoglouMehul T Dattani
Feb 1, 2014·EMBO Molecular Medicine·Jesús ArgenteLuis A Pérez-Jurado

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Methods Mentioned

BETA
hormone replacement treatment
X-ray
hormone replacement
hormone replacement therapy

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