PMID: 7932106Jan 1, 1994Paper

Influence of growth rate and nutrient limitation on monobactam production and peptidoglycan synthesis in Pseudomonas aeruginosa

Journal of Basic Microbiology
D G Allison, R D Nolan

Abstract

The effects of growth rate and nutrient limitation on monobactam production, peptidoglycan content and mean cell length in Pseudomonas aeruginosa was studied using continuous culture techniques. All three parameters increased progressively with growth rate, a greater response being shown under carbon limitation compared to that occurring under nitrogen limiting conditions. Interestingly, monobactum production mirrored peptidoglycan synthesis. In addition, the monobactam exhibited a broad range of antibacterial activity and bound preferentially to PBP 1A in the producing organism. Moreover, addition of the monobactam to a growing culture inhibited cell wall synthesis. These results are discussed in relation to the control and regulation of peptidoglycan synthesis.

References

Sep 1, 1990·FEMS Microbiology Letters·D G AllisonP Gilbert
Jan 1, 1986·Advances in Applied Microbiology·W L ParkerR B Sykes
Jan 1, 1987·Journal of Bacteriology·F Driehuis, J T Wouters
Jun 19, 1985·Journal of Chromatography·M E RogersG Holt
Jan 1, 1985·The Journal of Antimicrobial Chemotherapy·C P Conlon, C J Ellis
Jan 1, 1985·The Journal of Antimicrobial Chemotherapy·P Gilbert
Jan 1, 1985·Annual Review of Microbiology·M R Brown, P Williams
May 10, 1974·Annals of the New York Academy of Sciences·A L Demain
Nov 1, 1982·Journal of Bacteriology·J K Broome-Smith, B G Spratt
Jun 11, 1981·Nature·R B SykesJ S Wells
Jun 1, 1982·The Journal of Antibiotics·W L ParkerR B Sykes

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Citations

Jul 2, 1999·Journal of Applied Microbiology·B A CowellR P Schneider
Jan 1, 1996·Journal of Basic Microbiology·D G AllisonA R Williams

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