PMID: 9654239Jul 8, 1998Paper

Influence of GSTT1 genotype on sister chromatid exchange induction by styrene-7,8-oxide in cultured human lymphocytes

Environmental and Molecular Mutagenesis
T OllikainenH Norppa

Abstract

The genetic polymorphisms of glutathione S-transferases (GSTs), which are involved in the metabolic inactivation of various toxicants, have been suggested to be an important source of variation in individual response to genotoxic carcinogens. We have previously shown that donor GSTM1 genotype does not influence the induction of sister chromatid exchanges (SCEs) in cultured human lymphocytes by styrene-7,8-oxide (SO), a metabolite of styrene. Here, we expanded the study to GSTT1 polymorphism. SCEs were analyzed from 72-hr whole-blood lymphocyte cultures of five GSTT1 positive (at least one undeleted allele) and five GSTT1 null (gene homozygously deleted) donors, all GSTM1 positive, after a 48-hr treatment with 50 microM and 150 microM SO. SO clearly increased SCEs in cultures of all donors. The mean number of SCEs/cell induced by SO (individual mean SCEs from acetone-treated control cultures subtracted) was 1.7 (50 microM) and 1.4 (150 microM) times greater among the GSTT1 null individuals (4.83 at 50 microM, 18.98 at 150 microM) compared with the GSTT1 positive individuals (2.78 at 50 microM, 13.74 at 150 microM), the differences being statistically significant (P=0.006 and P=0.022, respectively). These findings show that the l...Continue Reading

Citations

Dec 4, 2003·Mutation Research·Hannu Norppa
May 10, 2005·Mutation Research·Leigh M Henderson, Günter Speit
Apr 20, 2004·Toxicology Letters·Hannu Norppa
Oct 6, 2000·Mutation Research·S Pavanello, E Clonfero
Oct 13, 1999·Mutation Research·M SomorovskáP Vodicka
Feb 26, 2010·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Gary GinsbergBabasaheb Sonawane
Feb 26, 2010·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Gary GinsbergBabasaheb Sonawane
Jan 10, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Nur DualeGunnar Brunborg
Jan 21, 2006·Pharmacogenetics and Genomics·Lucia MiglioreAri Hirvonen
Feb 13, 2007·Environmental Health : a Global Access Science Source·Eckart SchnakenbergWerner Schloot
Dec 6, 2006·Drug Metabolism Reviews·Pavel VodickaFranz Oesch
Jan 1, 2001·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·V HaufroidD Lison
Jul 23, 2003·International Journal of Hygiene and Environmental Health·Ricarda ThierHermann M Bolt
Jun 26, 2001·Environmental and Molecular Mutagenesis·A J Shield, B J Sanderson
Apr 30, 2003·Environmental and Molecular Mutagenesis·Annamaria BuschiniAntonio Mutti
Oct 11, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·José RueffJorge Francisco Gaspar

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