PMID: 6975939Oct 1, 1981Paper

Influence of H-2 antigen expression on killer T cell specificity, differentiation, and induction

Proceedings of the National Academy of Sciences of the United States of America
P J Fink, M J Bevan

Abstract

Murine cytotoxic T lymphocytes (CTL) and helper cells are H-2 antigen restricted in their specificity: recognition of foreign antigen by these cells requires the concomitant recognition of self-H-2 molecules. Which H-2 antigens T cells treat as "self" is determined by the particular H-2 antigens expressed on radioresistant cells of the thymus in which these T cells mature. Using tetraparental [(P1 + P2) leads to F1] radiation chimeras with in situ F1 thymuses, we have found that the H-2 genotype of the stem cells does not influence their H-2 restriction specificity. This has allowed us to use tetraparental chimeras that have been thymectomized and grafted with parental (P1, P2, or both) thymus lobes to study the requirements for H-2-restricted T--T interactions during CTL ontogeny and induction. In animals that have received thymus grafts of both parental origins, CTL display no preference for maturation within a syngeneic thymus graft, a finding that is not compatible with a suggested requirement for intrathymic H-2-restricted T--T interactions in the maturation of precursor CTL. We have also grafted thymectomized tetraparental radiation chimeras with thymus grafts from only one parent to compare the induction of P1 and P2 CTL...Continue Reading

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Citations

Jan 29, 1979·Biochimica Et Biophysica Acta·M R El-MaghrabiV L King
Mar 1, 1983·Biochimica Et Biophysica Acta·P V ReddyH H Schmid
Sep 18, 1990·Biochimica Et Biophysica Acta·T ThurenM Waite
Jun 1, 1982·The Journal of Experimental Medicine·D H Raulet, M J Bevan
Nov 1, 1984·Cellular Immunology·E L LarssonA Coutinho
Jan 1, 1988·Annals of the New York Academy of Sciences·D Cassell, J Forman
Feb 1, 1983·European Journal of Immunology·H Von Boehmer, K Turton

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