Influence of Hashimoto Thyroiditis on the Development of Thyroid Nodules and Cancer in Children and Adolescents

Journal of the Endocrine Society
Giorgio RadettiAndrea Corrias

Abstract

It is unclear whether patients with Hashimoto thyroiditis (HT) are predisposed to develop thyroid nodules and/or thyroid cancer. The objective of our study was therefore to assess the prevalence of thyroid nodules and/or cancer in patients with HT and to look for possible prognostic factors. A retrospective survey of 904 children/adolescents with HT (709 females, 195 males) regularly followed in nine Italian centers of pediatric endocrinology was performed. Median period of follow-up was 4.5 years (1.2 to 12.8 years). We evaluated free T4, TSH, thyroid peroxidase antibody (TPOAb), thyroglobulin antibodies, and thyroid ultrasound yearly. One hundred seventy-four nodules were detected, with an annual incidence rate of 3.5%. Ten nodules were malignant (8 papillary and 2 papillary follicular variant), giving a 5.7% prevalence of cancer among patients with nodules. The severity of hypoechogenity at ultrasound, TPOAb, and free T4 serum concentrations were predictive for the appearance of new nodules. Furthermore, a positive correlation was observed between TPOAb titer and the development of thyroid cancer. In conclusion, HT seems to influence the development of thyroid nodules, but not cancer in children and adolescents.

References

Apr 15, 2006·Hormones : International Journal of Endocrinology and Metabolism·Kalliopi Pazaitou-PanayiotouGrammati Galaktidou
May 27, 2006·Endocrine-related Cancer·M Niedziela
Jun 6, 2008·Archives of Pediatrics & Adolescent Medicine·Andrea CorriasUNKNOWN Study Group for Thyroid Diseases of Italian Society for Pediatric Endocrinology and Diabetology (SIEDP/ISPED)
May 18, 2010·Thyroid : Official Journal of the American Thyroid Association·Cüneyd AnilAlptekin Gursoy
May 22, 2010·Pediatric Radiology·Shivaram AvulaDenis Daneman
Aug 4, 2010·Archives of Pediatrics & Adolescent Medicine·Andrea CorriasUNKNOWN Study Group for Thyroid Diseases of Italian Society for Pediatric Endocrinology and Diabetology (SIEDP/ISPED)
Nov 6, 2010·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·F ConsortiA Antonaci
Nov 30, 2010·Hormones : International Journal of Endocrinology and Metabolism·Elias E MazokopakisIoannis K Starakis
Oct 18, 2011·Hormones : International Journal of Endocrinology and Metabolism·Vasiliki SkarpaAlphasteroula Papathanasiou
Jan 8, 2013·The Journal of Clinical Endocrinology and Metabolism·Bojana JankovicJerome M Hershman
Jan 1, 2012·Hormones : International Journal of Endocrinology and Metabolism·Massimo RizzoSalvatore Benvenga
Jun 6, 2013·The Journal of Clinical Endocrinology and Metabolism·Anjuli GuptaStephen A Huang
Mar 19, 2014·Best Practice & Research. Clinical Endocrinology & Metabolism·Marek Niedziela
May 3, 2014·Journal of Endocrinological Investigation·Francesco NardiPaolo Vitti
Aug 19, 2014·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Funda TaşliEnver Vardar
Oct 24, 2014·Thyroid : Official Journal of the American Thyroid Association·Mamatha KambalapalliGary L Francis
Apr 23, 2015·Thyroid : Official Journal of the American Thyroid Association·Gary L FrancisUNKNOWN American Thyroid Association Guidelines Task Force
Feb 13, 2016·The Journal of Clinical Endocrinology and Metabolism·Yang YuXiaohui Guo
Sep 14, 2016·International Journal of Pediatric Otorhinolaryngology·Sarah DermodyEarl H Harley
Sep 15, 2016·The New England Journal of Medicine·James A Fagin, Samuel A Wells

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Citations

Jan 14, 2020·Journal of Endocrinological Investigation·N AllenG Francis
Mar 12, 2020·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Tetsuya MizokamiJunichi Tajiri
Feb 6, 2020·Thyroid : Official Journal of the American Thyroid Association·Yin RenGregory W Randolph
Nov 13, 2020·Journal of Pediatric Endocrinology & Metabolism : JPEM·Maria Lucia SurDaniel Sur
Jan 21, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Tetsuya MizokamiJunichi Tajiri
Jun 15, 2021·Journal of Pediatric Endocrinology & Metabolism : JPEM·İrem Ceren ErbaşOlcay Evliyaoğlu

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Methods Mentioned

BETA
biopsy

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