Influence of heart rate variability and psychosocial factors on carotid stiffness, elasticity and impedance at menopause

Archives of Medical Research
Mauricio Sánchez-BarajasJuan Manuel Malacara

Abstract

The risk for cardiovascular diseases (CVD) increases after menopause. Heart rate variability (HRV), a measure of autonomic control, is a strong predictor of CVD. We undertook this study to test the association of ultrasound indices of early carotid atherosclerosis with HRV, symptoms, hormonal conditions, metabolic state, indicators of stress, and psychosocial factors in women at peri- and postmenopause, registering ambulatory R-R interval monitoring. In a cross-sectional design we studied 100 women at peri- and early postmenopause collecting anthropometry, symptoms, stress-related measurements, metabolic variables, cortisol, FSH and estradiol. We evaluated carotid ultrasonographic indices, and HRV was recorded for 4 h calculating time (SDNN, pNN50, rMSSD) and frequency domains (LF, HF, LF/HF) in women according to menopausal stage, estradiol levels, body mass index and waist circumference. Carotid indices were similar in peri- and postmenopausal women. For HRV measurements, SDNN was increased at postmenopause. Women with estradiol levels <109.2 pmol/L had increased intima-media thickness (IMT), resistive index, and systolic diameter. Using multivariate analysis, we found the associations of IMT positively with non-HDL-cholester...Continue Reading

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Citations

Apr 16, 2016·Medicine·Sheila Ohlsson WalkerXiaobin Wang
Jul 26, 2018·Physiological Research·J C OrriA Scala
Sep 22, 2018·Frontiers in Immunology·Massimo FioranelliMaria G Roccia
Sep 9, 2020·Menopause : the Journal of the North American Menopause Society·Georges Jabbour, Horia D Iancu

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